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Neuromedin B

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Cat.No：CLP0878 Solarbio

CAS：87096-84-2

Purity：≥95%

Appearance：Lyophilized powder

Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)

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Product Information

Product Type	Peptides
CAS	87096-84-2
Sequence(1LC)	GNLWATGHFM-NH2
Sequence(3LC)	Gly-Asn-Leu-Trp-Ala-Thr-Gly-His-Phe-Met-NH2
Molecular Formula	C52H73N15O12S1
Molecular Weight	1132.31
Purity	≥95%
Appearance	Lyophilized powder
Solubility	H2O：2 mg/mL; *Ultrasonic solubilization;
Salt Form	Trifluoroacetate salt
Source	Synthetic
Storage	Store at -20℃，2 years.(Avoid freeze/thaw cycles)
Category/Label	Neuropeptides and Related Peptides
Background	Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.
In Vitro	Potency to stimulate contraction of rat uterine smooth muscle, that is used as bioassay for isolation of Neuromedin B (NMB), is compared with Bombesin (BN). The relative potency, calculated on molar basis by taking BN as 100, is 48% for GRP and 4.9% for NMB. NMB also has contractile activity on rat stomach strip, but the potency (ratio of peptide concentration required to elicit 50% maximum response; EC50) is only 5% of BN (EC50 of BN/EC50 of NMB) and about 10% of GRP (EC50 of GRP/ EC50 of NMB).
In Vivo	Potencies of NMB and GRP for smooth muscle contraction of fundus in wild-type and NMB-R-deficient mice with ED50 of 14.4±2.3 (n=8) and 10.9±2.3 (n=8) in wild-type mice and NMB-R-deficient mice, respectively.
Reference	[1] Ohki-Hamazaki H. Neuromedin B. Prog Neurobiol. 2000 Oct;62(3):297-312.
Unit	Bottle
Specification	1mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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