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My CartCAS：383415-79-0
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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| Product Type | Peptides |
| CAS | 383415-79-0 |
| Sequence(1LC) | WYKHVASPRYHTVGRAAGLLMGL |
| Sequence(3LC) | Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu |
| Molecular Formula | C119H183N35O28S1 |
| Molecular Weight | 2584.04 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Solubility | DMSO：≥50 mg/mL; *Ultrasonic solubilization; |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Neuropeptides and Related Peptides |
| Background | Neuropeptide W-23 (human) is an endogenous ligand of the G-protein-coupled receptors GPR7 and GPR8. It dose-dependently inhibited cAMP accumulation induced by forskolin in CHO-GPR7 and CHO-GPR8 cells, with IC50 values of 0.025 and 0.178 nM, respectively. Intracerebroventricular administration of neuropeptide W-23 (human) in rats increased food intake and stimulated prolactin release. |
| In Vitro | Neuropeptide W-23 (human) (NPW-23) increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7. Neuropeptide W-23 (human) increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC. |
| In Vivo | Neuropeptide W-23 (human) (NPW-23) (0.3-3.0 nM; intracerebroventricular injection; 2 μL) increases total behavioral activity, including locomotion and grooming in conscious rats. Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats. |
| Reference | [1] Shimomura, Y. et al. J .Biol. Chem. 277, 35826 (2002). |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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