FMRF-NH2
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Cat.No：CLP0836 Solarbio
CAS：64190-70-1
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
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ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
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Ubiquitin
JAK/STAT
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Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
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PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
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Product Information
| Product Type | Peptides |
| CAS | 64190-70-1 |
| Sequence(1LC) | FMRF-NH2 |
| Sequence(3LC) | Phe-Met-Arg-Phe-NH2 |
| Molecular Formula | C29H42N8O4S1 |
| Molecular Weight | 598.77 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Solubility | DMSO：100 mg/mL; H2O：20 mg/mL; *Ultrasonic solubilization; |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Neuropeptides and Related Peptides |
| Background | A molluscan neuropeptide isolated from the ganglia of Macrocallista nimbosa. FMRF-amide seems to be involved in neuronal NO production in gastropoda. CAS Number (net): 64190-70-1. |
| In Vitro | In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acts on K+ channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide activates a novel K+ current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe, amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p. |
| In Vivo | Phe-Met-Arg-Phe, amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe, amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min. |
| Reference | [1] Jacob, TC. and JM. Kaplan, J. Neurosci. 23, 2122 (2003); [2] Madrid, K. et al. Peptides 15, 31 (1994); [3] Linacre, A. et al. J. Neurosci. 10, 412 (1990). |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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