Hemokinin 1 (mouse, rat)
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Cat.No：CLP0810 Solarbio
CAS：208041-90-1
Purity：≥95%
Appearance：Lyophilized powder
Storage：Store at -20℃，2 years.(Avoid freeze/thaw cycles)
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Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
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Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
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Product Information
| Product Type | Peptides |
| CAS | 208041-90-1 |
| Sequence(1LC) | RSRTRQFYGLM-NH2 |
| Sequence(3LC) | Arg-Ser-Arg-Thr-Arg-Gln-Phe-Tyr-Gly-Leu-Met-NH2 |
| Molecular Formula | C61H100N22O15S1 |
| Molecular Weight | 1413.67 |
| Purity | ≥95% |
| Appearance | Lyophilized powder |
| Solubility | DMSO：100 mg/mL; *Ultrasonic solubilization; |
| Salt Form | Trifluoroacetate salt |
| Source | Synthetic |
| Storage | Store at -20℃，2 years.(Avoid freeze/thaw cycles) |
| Category/Label | Neuropeptides and Related Peptides |
| Background | Hemokinin 1 (HK-1) is encoded by the preprotachykinin C (PPT-C) gene, which could be identified in hematopoietic cells in mouse. The undecapeptide HK-1 is a full agonist of all known three tachykinin NK1, NK2, and NK3 receptors with a remarkable selectivity for the NK1 receptor. In in vivo experiments it acts with potency similar to substance P. |
| In Vitro | Hemokinin 1 (mouse) (1?nM-3?μM) produces concentration-dependent contraction of RUB averaging 66±3% (n=6) of the maximal contraction produced by KCl (80?mM). Hemokinin 1 (mouse) (10?nM-10?μM) induces a quickly-developing contractile responses of GPI, as does the tachykinin NK3 receptor selective agonist senktide or neurokinin B (NKB). Hemokinin 1 (mouse) induces full agonist responses but with a 500 fold lower potency as compared to NKB. |
| In Vivo | Hemokinin 1 (mouse) (0.01-100?nmol/kg i.v., n=10) induces a dose-related hypotension that is maximal at the dose of 10?nmol/kg. For systolic blood pressure (SBP), the ED50 value is 0.2?nmol/kg (0.1-0.4?nmol/kg) for Hemokinin 1 (mouse). For diastolic blood pressure (DBP), the ED50 value is 0.1?nmol/kg (0.07-0.2?nmol/kg) for Hemokinin 1 (mouse). Hemokinin 1 (mouse) (0.1-100?nmol/kg, i.v.) induces a dose-related salivary secretion in atropine-pretreated rats. |
| Reference | [1] F.Bellucci et al., Br. J. Pharmacol., 135, 266(2002). |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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