Anti-TFRC Polyclonal Antibody
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Cat.No：K111932P Solarbio
Reactivity：Human
Application： IF,WB,IHC,ELISA
Storage：Store at -20℃. Avoid freeze/thaw cycles.
Host：Rabbit
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
GPCR & G Protein
Neuronal Signal Pathway
MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
Others
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Instruments
Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
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> Antibodies > Loading Control Antibodies > Plasmalemma > Anti-TFRC Polyclonal Antibody
Product Information
Experimental Images
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Product Information
| Name | Anti-TFRC Polyclonal Antibody |
| Host | Rabbit |
| Clone Type | Polyclonal Antibody |
| Subtype | IgG |
| Predicted Reactivity | Orangutan;Horse;Cat;Dog;Pig;Chicken |
| Dilution Ratio | WB 1:1000-3000. IHC 1:100-300. IF 1:50-200. |
| Target | TFRC |
| Background | Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738).Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity).A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738). |
| Swiss Prot | P02786 |
| Gene ID | 7037 |
| Subcellular Location | Cell membrane Secreted |
| Immunogen | Recombinant protein of human TFRC |
| Public Immunogen Range | 101-450aa |
| Calculated MW | 85kDa |
| Purification Method | Affinity purification |
| Storage Buffer | PBS with 50% Glycerol，0.03% Proclin300，0.5% BSA，pH 7.3. |
| Storage | Store at -20℃. Avoid freeze/thaw cycles. |
| Unit | Piece |
| Y-Dilution Ratio | WB 1:1000-3000. IHC 1:100-300. IF 1:50-200. ELISA 1:8000-80000. |
| Specification | 50ul 100ul |
| Reactivity | Human |
| Application | IF WB IHC ELISA |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Kindly reminder：Quick spin before use. If you have any questions, please contact us.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Experimental Images
Western blot analysis with TFRC antibody diluted at 1:2000.Lane: 293T,Jurkat,HEK293.
Immunohistochemistry of paraffin-embedded Human colorectal cancer with TFRC antibody diluted at 1:200.
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