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Ciclesonide

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Cat.No：IC2720 Solarbio

CAS：126544-47-6

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	126544-47-6
Name	Ciclesonide
Molecular Formula	C₃₂H₄₄O₇
Molecular Weight	540.69
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	O=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](CCC3=CC4=O)([H])[C@]([C@]3(C=C4)C)([H])[C@@H](O)C5)(O[C@H](C6CCCCC6)O1)[C@]25C)COC(C(C)C)=O
Target Point	Glucocorticoid Receptor
Passage	GPCR & G Protein
Background	Ciclesonide is a glucocorticoid.
In Vitro	Ciclesonide，the parent compound，undergoes hydrolysis by ester cleavage at the C21 position to the active metabolite，desisobutyryl-ciclesonide(des-CIC)，followed by reversible formation of fatty acid esters within the lung cells. Ciclesonide(5 μM)is rapidly hydrolyzed by normal human bronchial epithelial(NHBE)cells(approximately 30% conversion at 4h)，with almost complete conversion by 24 h[1].
Data Literature Source	[1]. Mutch，E.，et al.，The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue. Biochem Pharmacol，2007. 73(10): p. 1657-64.
Unit	Bottle
Specification	5mg 10mg

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Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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