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My CartCAS：113-59-7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow Solid
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| CAS | 113-59-7 |
| Name | Chlorprothixene |
| Molecular Formula | C18H18NSCl |
| Molecular Weight | 315.86 |
| Solubility | Soluble in DMSO ≥1mg/mL;Soluble in Water ＜ 0.1mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 204-032-8 |
| MDL | MFCD00869180 |
| SMILES | CN(C)CC/C=C1C2=C(SC3=C\1C=CC=C3)C=CC(Cl)=C2 |
| InChIKey | WSPOMRSOLSGNFJ-AUWJEWJLSA-N |
| InChI | InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7- |
| PubChem CID | 667467 |
| Target Point | Dopamine Receptor; Histamine Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | Chlorprothixene has a high affinity for dopamine and histamine receptors. |
| In Vitro | Chlorprothixene与多巴胺和组织胺受体具有强结合力，如 D1，D2，D3，D5，和H1，Ki值分别为 18nM，2.96 nM，4.56 nM，9 nM，和3.75 nM，但是对H3亲和力不强，Ki>1000 nM。[1] Chlorprothixene也与稳定转染HEK-293细胞的小鼠5-HT6受体，和短暂表达COS-7细胞的小鼠5-HT7受体具有高亲和力，Ki值分别为3 nM和5.6 nM。[2] 用Chlorprothixene处理Vero 76细胞，导致SARS-CoV复制受抑制。[3] |
| In Vivo | Clorprothixene作用于脑部，抑制突触后的中脑缘的多巴胺能药D1和D2受体，降低下丘脑和垂体激素的释放。过量Chlorprothixene作用于肾上腺髓质和脑部，抑制 iproniazid作用于Reserpine诱导的Catecholamines释放而提供的保护，且作用于小鼠脑部，降低5HT，NE和 DA。[4] 用Chlorprothixene处理小鼠支气管上皮细胞，通过抑制酸性鞘磷脂酶(Asm)而不是中性鞘磷脂酶(Nsm)，修复正常神经鞘氨醇浓度，降低肺囊肿性纤维化(CF)鼠的炎症发生，且阻止感染绿脓杆菌。[5] |
| Data Literature Source | [1] von Coburg Y，et al. Bioorg Med Chem Lett. 2009，19 (2)，538-542. [2] Roth BL，et al. J Pharmacol Exp Ther. 1994，268 (3)，1403-1410. [3] Barnard DL，et al. Antiviral Res. 2008，79 (2)，105-113. [4] GEY KF，et al. J Pharmacol Exp Ther. 1961，133，18-24. [5] Becker KA，et al. Am J Respir Cell Mol Biol，2010，42(6)，716- |
| Unit | Bottle |
| Specification | 50mg 100mg |
是一种多巴胺 (dopamine) 和组胺 (histamine) 受体拮抗剂，对多巴胺和组胺受体有高度的亲和力。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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