{{cart_num}}
My CartCAS：38183-03-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Light yellow to green Solid
Qty：
Size：
| CAS | 38183-03-8 |
| Name | 7,8-Dihydroxyflavone |
| Molecular Formula | C15H10O4 |
| Molecular Weight | 254.24 |
| Solubility | Soluble in DMSO ≥20mg/mL |
| Purity | HPLC≥98% |
| Appearance | Light yellow to green Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 253-812-4 |
| MDL | MFCD00006836 |
| SMILES | O=C1C=C(C2=CC=CC=C2)OC3=C(O)C(O)=CC=C13 |
| InChIKey | COCYGNDCWFKTMF-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H |
| PubChem CID | 1880 |
| Target Point | Trk Receptor |
| Passage | Protein Tyrosine Kinase/RTK;Neuronal Signaling |
| Background | 7,8-Dihydroxyflavone is a potent and selective TrkB agonist. |
| Biological Activity | 7,8-Dihydroxyflavone (7,8-DHF) 是有效的、选择性的TrkB受体激动剂（Kd≈320 nM）。TrkB受体是脑源性神经营养因子的主要信号受体。[1-3] |
| IC50 | TrkB receptor:320nM(Kd) [1] |
| In Vitro | 250nM 7，8-DHF特异性激活TrkB，而不激活TrkA或TrkC。除了大脑皮质和海马神经元，7，8-DHF还保护其他细胞如视网膜神经节细胞(RGC)和PC12细胞免受氧化应激诱导的凋亡和细胞死亡。因此，7，8-DHF具有神经保护作用[1]。 |
| In Vivo | 7，8-Dihydroxyflavone是一种具有生物效应的化合物，对小鼠进行腹腔注射或口服给药后，7，8-Dihydroxyflavone能够穿过血脑屏障、激活TrkB及其下游PI3K/Akt和MAPK。7，8-DHF在外伤性脑损伤时促进皮层神经元的生存能力、减少其凋亡。在受伤后3小时进行7，8-DHF给药，7，8-DHF能通过PI3K/Akt信号通路途径减少组织损伤。7，8-DHF的处理在小鼠中并不诱导任何明显的毒性作用，长期给药对小鼠没有毒性。7，8-DHF对阿尔茨海默病有较强的治疗效果，能通过激活肌肉TrkB抑制肥胖[1]。 |
| Cell Experiment | PC12 cells以104/孔的密度接种于96孔板。用1-25 μM 7，8-DHF对细胞进行预处理，处理1小时，然后将细胞用6-OHDA处理24小时。在7，8-DHF处理前，加入PI3K抑制剂LY294002或MEK抑制剂PD98059孵育30分钟。实验结束后，PC12细胞用20 μl MTT溶液孵育4小时(37 C)，深蓝色的甲瓒产物溶解于150μl DMSO中，测定其在570 nm处的吸光值。[3] |
| Animal Experiment | Animal Models: Wistar雄性大鼠；APPswe/PS1dE9 雄性转基因小鼠; Dosages: 0.1 mg/kg，0.3 mg/kg，1 mg/kg和3 mg/kg(大鼠)；0.1 mg/kg(小鼠);Administration: 腹腔注射[2] |
| Data Literature Source | [1] Liu C，et al. Transl Neurodegener. 2016，5:2. [2] Bollen E，et al. Behav Brain Res. 2013，257:8-12. [3] Han XH，et al. Neurosci Lett. 2014，581:85-8. |
| Unit | Bottle |
| Specification | 20mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
