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My CartCAS：52152-93-9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥95%
Appearance：Off white to yellow Solid
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| CAS | 52152-93-9 |
| Name | Cefsulodin Sodium |
| Molecular Formula | C22H19N4O8S2·Na |
| Molecular Weight | 554.53 |
| Solubility | Soluble in Water ≥50mg/mL |
| Purity | HPLC≥95% |
| Appearance | Off white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 257-692-4 |
| MDL | MFCD07793338 |
| SMILES | O=C(N[C@H]1[C@@]2([H])SCC(C[N+]3=CC=C(C(N)=O)C=C3)=C(C([O-])=O)N2C1=O)[C@@H](C4=CC=CC=C4)S(=O)([O-])=O.[Na+] |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Cefsulodin Sodium is a β-lactam antibiotic that inhibits cell wall synthesis by competitively inhibiting penicillin-binding protein (PBP) peptide crosslinking and transpeptide. |
| Biological Activity | Cefsulodin (Sulcephalosporin) is a β-lactam antibiotic and inhibits mPTPB with the IC50 of 16 μM.[1] |
| In Vitro | Cefsulodin is a third generation β-lactam cephalosporin antibiotic，as a novel pTyr pharmacophore for mPTPB. Cefsulodin has also been found to exhibit inhibitory activity against SHP2 and PTP1B[1]. |
| In Vivo | Cefsulodin shows maximum plasma and tissue levels 15-30 minutes after administration of a single dose of 20 mg/kg. In mice，the renal level of cefsulodin is slightly lower than the plasma level，and in rats and dogs，the renal level of cefsulodin is higher than the plasma level. The concentration of cefsulodin in the lung is relatively high in rats and dogs. On the other hand，the hepatic level is very low in all test animal species. The main route of excretion of cefsulodin is the urinary tract. About 80% of cefsulodin is excreted into the urine[3]. |
| Animal Experiment | Animal Models: SLC-ddY mice，JCL-Sprague Dawly rats，mongrel dogs; Dosages: 20 mg/kg; Administration: s.c.[2] |
| Data Literature Source | [1] He R，et al. ACS Med Chem Lett. 2015，6(12):1231-5. [2] Tsuchiya K，et al. J Antibiot (Tokyo). 1978，31(6):593-7. [3] Tsuchiya K，et al. J Antibiot (Tokyo). 1978，31(6):593-7. |
| Unit | Bottle |
| Specification | 25mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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