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Bufexamac

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Cat.No：IB1870 Solarbio

CAS：2438-72-4

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	2438-72-4
Name	Bufexamac
Molecular Formula	C₁₂H₁₇NO₃
Molecular Weight	223.27
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 219-451-1
MDL	MFCD00078936
SMILES	O=C(NO)CC1=CC=C(OCCCC)C=C1
InChIKey	MXJWRABVEGLYDG-UHFFFAOYSA-N
InChI	InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)
PubChem CID	2466
Target Point	HDAC，IFN-α，COX
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	It is an inhibitor of HDAC6 and HDAC10 with anti-inflammatory activity; it is also a COX inhibitor that targets IFN-α.
In Vitro	Bufexamac是IIB型组蛋白(HDAC6 和 HDAC10)去乙酰化酶的特异性抑制剂。Bufexamac会抑制外周血单核细胞内IFN-α分泌[1]。 Bufexamac是一种非甾类的消炎剂[2]。
Data Literature Source	[1]. Bantscheff，M.，et al.，Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol，2011. 29(3): p. 255-65. [2]. Kranke，B.，et al.，Epidemiological significance of bufexamac as a frequent and relevant contact sensitizer. Contact Dermatitis，1997. 36(4): p. 212-5.
Unit	Bottle
Specification	25mg 50mg 100mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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