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My CartCAS：202189-78-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 202189-78-4 |
| Name | Bilastine |
| Molecular Formula | C28H37N3O3 |
| Molecular Weight | 463.61 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD09837814 |
| SMILES | CCOCCN1C2=CC=CC=C2N=C1C3CCN(CC3)CCC4=CC=C(C=C4)C(C)(C)C(=O)O |
| Target Point | Histamine Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | It is a histamine H1 receptor antagonist and can be used in the related research of allergic rhinoconjunctivitis and urticaria. |
| Biological Activity | Bilastine是一种新型耐受的、无镇静作用的抗组胺剂，针对H1 receptor。[1] |
| In Vitro | Bilastine has a high specific affinity for the H1-receptor but it has no or very low affinity for 30 other tested receptors[1]. It is lack of significant antagonism against serotonin，bradykinin，leukotriene D4，calcium，muscarinic M3-receptors，α1-adrenoceptors，β2-adrenoceptors，and H2- and H3- receptors[2]. |
| In Vivo | Bilastine is efficacious in all nasal symptoms including obstruction and in eye symptoms in patients with allergic rhinoconjunctivitis. Bilastine is well tolerated. In the fasting state bilastine is quickly absorbed，but the absorption is slowed when it is taken with food or fruit juice. In vivo studies in rats have demonstrated reduction in histamine-stimulated smooth muscular contraction，bronchospasms，endothelial permeability，and microvascular extravasation[1]. |
| Data Literature Source | [1] Ole D. Wolthers. BioMed Research International. 2013，626837. [2] Corcóstegui R，et al. Drugs R D. 2005，6(6):371-84. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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