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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > BI-D1870CAS：501437-28-1
Molecular Formula：C19H23F2N5O2
Molecular Weight：391.42
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 501437-28-1 |
| Name | BI-D1870 |
| Molecular Formula | C19H23F2N5O2 |
| Molecular Weight | 391.42 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00000022 |
| SMILES | CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C |
| Target Point | Ribosomal S6 Kinase (RSK) |
| Passage | MAPK |
| Background | BI-D1870 is an ATP-competitive RSK inhibitor, inhibits RSK1, RSK2, RSK3, RSK4. |
| Biological Activity | BI-D1870 是ATP 竞争性的 RSK 抑制剂，抑制 RSK1、RSK2、RSK3、RSK4 的IC50 值分别为 31 nM、24 nM、18 nM、15 nM。[1-5] |
| IC50 | 31nM(RSK1)，24nM(RSK2)，18nM(RSK3)，15nM(RSK4)[1] |
| Data Literature Source | [1]. Sapkota GP，et al. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401(1):29-38. [2]. Ciceri P，et al. Dual kinase-bromodomain inhibitors for rationally designed polypharmacology. Nat Chem Biol. 2014 Mar 2. [3]. Takada I，et al. The ribosomal S6 kinase inhibitor BI-D1870 ameliorated experimental autoimmune encephalomyelitis in mice. Immunobiology. 2016 Feb;221(2):188-92. [4]. Roffe M，et al. Two widely used RSK inhibitors，BI-D1870 and SL0101，alter mTORC1 signaling in a RSK-independent manner. Cell Signal. 2015 Aug;27(8):1630-42. [5]. Chiu CF，et al. Antitumor effects of BI-D1870 on human oral squamous cell carcinoma. Cancer Chemother Pharmacol. 2014 Feb;73(2):237-47 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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