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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > ASP-3026CAS：1097917-15-1
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1097917-15-1 |
| Name | ASP-3026 |
| Molecular Formula | C29H40N8O3S |
| Molecular Weight | 580.75 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-258-5 |
| MDL | MFCD00064808 |
| SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC |
| Target Point | ALK |
| Passage | Protein Tyrosine Kinase/RTK;Angiogenesis |
| Background | It is a highly active ALK inhibitor. |
| Biological Activity | ASP3026 是一种新型选择性ALK 抑制剂，其IC50 为3.5 nM.[1] |
| IC50 | ALK: 3.5nM[1] |
| In Vitro | ASP3026在酪氨酸激酶中比PF02341066显示更强的选择性抑制ALK活性。ASP3026抑制人非小细胞肺癌肿瘤细胞系NCI-H2228中内源性表达EML4-ALK突变体3的生长，IC 50为64.8 nM。[1] |
| In Vivo | 给皮下NCI-H2228肿瘤异种移植物小鼠为每天口服ASP3026两次至14天，诱导了剂量依赖性的抗肿瘤效应，在1毫克/千克开始作用，在10，30和100毫克/千克时有较强的抑制作用。 [1] |
| Data Literature Source | [1] Sadao Kuromitsu，et al. AACR 102nd Annual Meeting，2011. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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