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AZD-5104

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Cat.No：IA3670 Solarbio

CAS：1421373-98-9

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	1421373-98-9
Name	AZD-5104
Molecular Formula	C₂₇H₃₁N₇O₂
Molecular Weight	485.58
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD28899992
SMILES	C=CC(NC1=CC(NC2=NC=CC(C3=CNC4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
Target Point	EGFR
Passage	Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling
Background	AZD-5104 is an EGFR inhibitor.
Biological Activity	AZ5104，是AZD-9291的脱甲基代谢物，是一种有效的EGFR抑制剂，作用于EGFR (L858R/T790M)，EGFR (L858R)，EGFR (L861Q)，和EGFR (野生型)，IC50分别为<1 nM，6 nM，1 nM，和25 nM。[1]
In Vitro	AZ5104对ex19del(2 nM 在PC-9中)，T790M(2 nM在H1975中)，和野生型EGFR(33 nM在LOVO中)细胞系表现出良好的疗效。AZ5104引起细胞活性的抑制，对H1975(T790M/L858R)，PC-9(ex19del)，Calu 3(WT)，和NCI-H2073(WT)的IC50分别为3.3 nM，2.6 nM，80 nM，和53 nM。[1]
In Vivo	在C/L858R和C/L+T小鼠中，AZ5104(5 mg/kg/d，p.o.)诱导显著且持续的肿瘤退化。[1]
Data Literature Source	[1] Cross DA，et al. Cancer Discov. 2014，4(9)，1046-1061.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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