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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > AZ-191CAS：1594092-37-1
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to brown solid
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| CAS | 1594092-37-1 |
| Name | AZ-191 |
| Molecular Formula | C24H27N7O |
| Molecular Weight | 429.52 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to brown solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28015098 |
| SMILES | CN1C2=CN=CC=C2C(C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3)=C1 |
| Target Point | DYRK |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | It is a potent and selective inhibitor of DYRK1B. |
| Biological Activity | AZ191是一种有效的选择性DYRK1B抑制剂，无细胞试验中IC50为17 nM，比作用于DYRK1A 和 DYRK2选择性分别高5和110倍。[1] |
| In Vitro | AZ191选择性的抑制了DYRK1B丝氨酸/苏氨酸的激酶活性而对其酪氨酸激酶自磷酸化没有效应。在HEK-293细胞中，比起对DYRK1A，AZ191展示了对DYRK1B更高的的抑制效应，并且抑制了CCND1磷酸化。在HD1B细胞中，AZ191强烈的抑制了细胞周期调节子(p21Cip1 和 p27Kip1)的含量，并且增强了细胞周期的进程。[1] |
| Data Literature Source | [1] Ashford AL，et al. Biochem J. 2014，457(1)，43-56. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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