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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > S0859CAS：1019331-10-2
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1019331-10-2 |
| Name | S0859 |
| Molecular Formula | C29H24ClN3O3S |
| Molecular Weight | 530.04 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD23136018 |
| SMILES | CC1=CC=C(C=C1)CN(CC2=CC=C(C=C2)C3=CC=CC=C3S(=O)(=O)NC#N)C(=O)C4=CC=CC=C4Cl |
| Target Point | Na+/HCO3- Cotransporter |
| Passage | Membrane Transporter&Ion Channel |
| Background | S0859, an N-cyanosulfonamide compound, is a novel, selective, high-affinity general inhibitor of Na+/HCO3- co-transporter (NBC). |
| In Vitro | Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues[1]. |
| Data Literature Source | [1]. Larsen AM，Krogsgaard-Larsen N，Lauritzen G，et al. Gram-scale solution-phase synthesis of selective sodium bicarbonate co-transport inhibitor S0859: in vitro efficacy studies in breast cancer cells. ChemMedChem. 2012 Oct;7(10):1808-14. |
| Unit | Bottle |
| Specification | 1mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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