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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > Acebutolol HydrochlorideCAS：34381-68-5
Molecular Formula：C18H28N2O4·HCl
Molecular Weight：372.89
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 34381-68-5 |
| Name | Acebutolol Hydrochloride |
| Molecular Formula | C18H28N2O4·HCl |
| Molecular Weight | 372.89 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 251-980-3 |
| MDL | MFCD00078860 |
| SMILES | CCCC(NC1=CC=C(OCC(O)CNC(C)C)C(C(C)=O)=C1)=O.Cl |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| Background | It is a beta-adrenergic receptors (beta-adrenergic receptor) antagonist. |
| Biological Activity | Acebutolol HCl是beta-adrenergic receptors（β-肾上腺素能受体）拮抗剂.Acebutolol对心律以及弱的内在拟交感行为具有稳定和Quinidine样的作用。[1-5] |
| In Vitro | Acebutolol抑制大鼠脑P2片段摄取NA，IC50为0.25 mM。[1]Acebutolol抑制125I标记的CYP结合到人体脂肪细胞膜上，并能完全取代所有特异性结合的放射性配体。Acebutolol完全抑制1 μM Isoproterenol引起的脂肪分解活性。Acebutolol是心脏选择性的拮抗剂，具有较低的脂溶性。[2]Acebutolol(不与LDL结合)作用于J774巨噬细胞，与Alprenolol和 Oxprenolol(与LDL结合)相比，对胆固醇酯的细胞内积累具有更强的抑制作用。[3] |
| In Vivo | Acebutolol(30 mg/kg)处理 Sprague-Dawley大鼠，1分钟和10分钟后测量，心输出量分别下降65% 和 31%。Acebutolol(30 mg/kg)处理Sprague-Dawley大鼠，1分钟或10分钟后测量，大部分器官的局部血流量(RBF)都显著降低。[5] |
| Cell Experiment | Acebutolol(10 mg/kg)单独静脉注射给药大鼠，血浆清除率为61.9mL/min/kg，分布容积为9.6L/kg，消除半衰期为1.8小时。Acebutolol(50 mg/kg)单独静脉注射给药大鼠，血浆清除率为46.5 mL/min/kg，分布容积为9.5L/kg，消除半衰期为2.3小时。[4] |
| Data Literature Source | [1] Street JA，et al. Eur J Pharmacol，1984，102(2)，315-324. [2] Mauriège P，et al. J Lipid Res，1988，29(5)，587-60 [3] Seifert T，et al. Chem Phys Lipids，1997，85(1)，13-21. [4] Piquette-Miller M，et al. Biopharm Drug Dispos，1997，18(6)，543-556. [5] Mostafavi S，et al. Biopharm Drug Dispos，2000，21(4)，121-12 |
| Unit | Bottle |
| Specification | 25mg 50mg 100mg |
是beta-adrenergic receptors（β-肾上腺素能受体）拮抗剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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