Alectinib Hydrochloride
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Cat.No：IA3070 Solarbio
CAS：1256589-74-8
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：White to off-white Solid
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> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > Alectinib Hydrochloride
Product Information
| CAS | 1256589-74-8 |
| Name | Alectinib Hydrochloride |
| Molecular Formula | C30H34N4O2·HCl |
| Molecular Weight | 519.08 |
| Solubility | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years |
| MDL | MFCD27987893 |
| SMILES | [H]Cl.N#CC1=CC2=C(C3=C(N2)C(C)(C4=CC(N5CCC(CC5)N6CCOCC6)=C(C=C4C3=O)CC)C)C=C1 |
| Target Point | ALK |
| Passage | Protein Tyrosine Kinase/RTK;Angiogenesis |
| Background | Alectinib Hydrochloride is a potent and selective ALK inhibitor. |
| Biological Activity | Alectinib (AF802, CH5424802, RO5424802, RG-7853)是一种选择性抑制ALK酪氨酸激酶的口服药物，IC50为1.9 nM。[1] |
| In Vitro | Alectinib抑制ALK，IC50为1.9 nM，相对其他丝氨酸/苏氨酸激酶，对ALK具有高选择性。对于耐crizotinib的ALK突变，如L1196M、F1174L、R1275Q和C1156Y，Alectinib也十分有效。在KARPAS-299(lymphoma)，NB-1(neuroblastoma)和 NCI-H2228(lung cancer)ALK阳性的细胞系中，alectinib可抑制其细胞增殖，IC50分别为3、4.5和53 nM[1]。 |
| In Vivo | 口服给药浓度为2-20 mg/kg(q.d.)时，Alectinib可浓度依赖性的抑制EML4-ALK阳性的NCI-H2228异种移植瘤，在EML4-ALK L1196M驱动的肿瘤中也有显著的效果[1]。在具有ALK基因突变(改变)的癌症中，Alectinib具有抗肿瘤活性[2]。 |
| Cell Experiment | Animal Models: 通过皮下接种肿瘤的SCID小鼠；Dosages: 60 mg/kg；Administration: 口服[2] |
| Data Literature Source | [1] Song Z，et al. Acta Pharm Sin B. 2015，5(1):34-7. [2] Kodama T，et al. Cancer Lett. 2014，351(2):215-21. [3] Ke Yang，et al. Exp Mol Med. 2017，49(3): e303. |
| Unit | Bottle |
| Specification | 10mg 25mg |
是一种有效、选择性 ALK 抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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