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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > DL-AdrenalineCAS：329-65-7
Molecular Formula：C9H13NO3
Molecular Weight：183.2
Storage：Powder:-20℃，2 years
Purity：≥98%
Appearance：Yellow to yellowish brown Solid
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| CAS | 329-65-7 |
| Name | DL-Adrenaline |
| Molecular Formula | C9H13NO3 |
| Molecular Weight | 183.2 |
| Solubility | Soluble in DMSO≥10mg/mL(Need ultrasonic or Water bath);Soluble in Ethanol＜1mg/mL;Soluble in Water<2mg/mL |
| Purity | ≥98% |
| Appearance | Yellow to yellowish brown Solid |
| Storage | Powder:-20℃，2 years |
| EC | EINECS 206-347-6 |
| MDL | MFCD00063027 |
| SMILES | OC(C1=CC(O)=C(O)C=C1)CNC |
| InChIKey | UCTWMZQNUQWSLP-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 |
| PubChem CID | 838 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| Background | It is an adrenergic receptor agonist, a hormone and neurotransmitter secreted by the adrenal medulla. |
| Biological Activity | DL-Epinephrine是肾上腺素的消旋体。L-Epinephrine是由肾上腺髓质分泌的激素。它是α-adrenergic和β-adrenergic受体激动剂。[1-4] |
| In Vivo | 与未处理的对照眼相比，将12微升体积的1％L-肾上腺素硼酸盐溶液施用于12只猴子的一只眼睛的角膜上，分别使通过虹膜和睫状体的血流减少59％和20％[ 1]。肾上腺素是一种直接作用的拟交感神经药α-肾上腺素能和β-肾上腺素能激动剂，具有环腺苷一磷酸介导的，复杂的，对许多靶器官的双向药理作用[2]。在年轻成年大鼠中，肾上腺素的内源性释放促进了对于时间相关事件的稳定记忆形成。肾上腺素通过增加调节记忆所需的血糖水平来增强年轻成年大鼠的记忆[3]。肾上腺素是心肺复苏(CPR)期间用于逆转心脏骤停的主要药物。肾上腺素通过α-1-肾上腺素能受体激动剂作用增加CPR期间的动脉血压和冠状动脉灌注[4]。 |
| Animal Experiment | 大鼠：对于免疫组织化学实验，大鼠接受培训后立即皮下注射生理盐水(0.9％)，葡萄糖(250 mg / kg)或肾上腺素(0.1 mg / kg)，然后返回保持笼[3] 。 |
| Data Literature Source | [1]. Alm A，et al. The effect of topical l-epinephrine on regional ocular blood flow in monkeys. Invest Ophthalmol Vis Sci. 1980 May;19(5):487-91. [2]. Simons FE，et al. First-aid treatment of anaphylaxis to food: focus on epinephrine. J Allergy Clin Immunol. 2004 May;113(5):837-44. [3]. Morris KA，et al. Epinephrine and glucose modulate training-related CREB phosphorylation in old rats: relationships to age-related memory impairments. Exp Gerontol. 2013 Feb;48(2):115-27. [4]. Callaway CW，et al. Epinephrine for cardiac arrest. Curr Opin Cardiol. 2013 Jan;28(1):36-42. |
| Unit | Bottle |
| Specification | 200mg 500mg 1g |
是一种肾上腺素受体激动剂，是肾上腺髓质分泌的一种激素和神经递质。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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