LY-2119620
Cat.No:IL1960 Solarbio
CAS:886047-22-9
Molecular Formula:C19H24ClN5O3S
Molecular Weight:437.94
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to yellow Solid
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Small Molecule Compounds >
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LY-2119620CAS:886047-22-9
Molecular Formula:C19H24ClN5O3S
Molecular Weight:437.94
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to yellow Solid
Qty:
Size:
CAS | 886047-22-9 |
Name | LY-2119620 |
Molecular Formula | C19H24ClN5O3S |
Molecular Weight | 437.94 |
Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water < 0.1mg/mL |
Purity | ≥98% |
Appearance | White to yellow Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL | MFCD27996043 |
SMILES | NC1=C(C(NC2CC2)=O)SC3=C1C(C)=C(Cl)C(OCC(N4CCN(C)CC4)=O)=N3 |
Target Point | mAChR |
Passage | Neuronal Signaling;GPCR & G Protein |
Background | LY-2119620 is a high affinity muscarinic M2/M4 receptor agonist. |
Biological Activity | LY2119620 是一种高亲和力的毒蕈碱性 M2/M4 受体激动剂。[1] |
In Vitro | LY2119620分别显示M2和M4受体的适度变构激动作用为23.2±2.18%和16.8±5.01%。在M1,M3和M5受体处观察到LY2119620的最小变构激动(<20%)。发现用于未占据受体上的变构结合位点的LY2119620的可变KB始终为约1.9至3.4μM。结果显示,加入10μMLY2119620后,M2受体的Bmax从793±1.95 fmol / mg增加到2850±162 fmol / mg,M4受体的Bmax增加约5倍,284±18.3 fmol / mg至1340±42.2 fmol / mg [1]。 |
Kinase Experiment | 通过将15μg膜,正构配体(100μM)和各种浓度的[3H] LY2119620(0.2至60nM)在25℃温育1小时来实现[3H] LY2119620平衡结合。特异性结合对时间数据适合于单位点特异性结合模型,并且计算每个正构配体的变构分子的Bmax和Kd [1]。 |
Data Literature Source | [1]. Croy CH,et al. Characterization of the novel positive allosteric modulator,LY2119620,at the muscarinic M(2) and M(4) receptors. Mol Pharmacol. 2014 Jul;86(1):106-15 |
Unit | Bottle |
Specification | 2mg 5mg |
Remark:These protocols are for reference only. Solarbio does not independently validate these methods.
Note:
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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