Dalbavancin
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Cat.No：ID2760 Solarbio
CAS：171500-79-1
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥95%
Appearance：Solid
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PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
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Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
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Product Information
| CAS | 171500-79-1 |
| Name | Dalbavancin |
| Molecular Formula | C88H100Cl2N10O28 |
| Molecular Weight | 1816.69 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥95% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 206-141-6 |
| MDL | MFCD00037268 |
| SMILES | O[C@@H]([C@@H](O)[C@@H]1O)[C@H](O[C@@H]1CO)OC2=C(C3=CC([C@@](C4=O)([H])NC([C@@](NC([C@](NC([C@@](NC5=O)([H])C6)=O)([H])C(C=C7OC(C=C8[C@H]5NC)=C(C=C8)O)=C(C(O)=C7)Cl)=O)([H])C9=CC%10=C(O[C@H](O[C@H](C(O)=O)[C@@H](O)[C@@H]%11O)[C@@H]%11NC(CCCCCCCCC(C)C)=O)C(OC%12=CC=C6C=C%12)=C9)=O)=CC=C3O)C([C@@](NC([C@](N4)([H])[C@@H](C%13=CC=C(O%10)C(Cl)=C%13)O)=O)([H])C(NCCCN(C)C)=O)=CC(O)=C2 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | It is a lipoglycopeptide antibiotic. |
| Biological Activity | Dalbavancin是一种脂蛋白肽类抗生素，对革兰氏阳性菌 (bacteria) 具有活性。[1-2] |
| In Vitro | 达巴万星是一种经肠外注射的半合成脂糖肽，用于对抗耐药革兰氏阳性病原体引起的感染。达巴万星对革兰氏阳性病原菌(包括金黄色葡萄球菌(MRSA)、VISA和VRE的非VanA株)具有较强的体外杀菌活性。达巴万星被开发用于治疗复杂的皮肤和皮肤结构感染(csssi)，主要是由MRSA和β-溶血性链球菌引起的，与现有的糖肽治疗剂相比，它显示出更大的效力。 |
| In Vivo | 达巴万星(15-240 mg/kg；腹腔注射；每36小时或72小时；连续14天；雌性BALB/c小鼠)治疗在所有剂量方案中小鼠的存活率为80%至100%[1]。动物模型：雌性BALB/c小鼠(6-8周)，用炭疽杆菌Ames株攻击[1]剂量：15mg/kg、30mg/kg、60mg/kg、120mg/kg、240mg/kg，腹腔注射，每36h或72h一次，连续14d，疗效为80-100%，以42天存活率为指标，在激发后24小时开始治疗时，每36小时15至120 mg/kg或每72小时30至240 mg/kg的治疗方案。 |
| Data Literature Source | [1]. Heine HS，et al. Activity of dalbavancin against Bacillus anthracis in vitro and in a mouse inhalation anthrax model. Antimicrob Agents Chemother. 2010 Mar;54(3):991-6. [2]. Bennett JW，et al. Dalbavancin in the treatment of complicated skin and soft-tissue infections: a review. Ther Clin Risk Manag. 2008 Feb;4(1):31-40 |
| Unit | Bottle |
| Specification | 5mg 10mg |
是一种脂糖肽类抗生素。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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