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My CartCAS：68401-81-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 68401-81-0 |
| Name | Ceftizoxime |
| Molecular Formula | C13H13N5O5S2 |
| Molecular Weight | 383.41 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 629-729-8 |
| MDL | MFCD00072000 |
| SMILES | O=C(C(N12)=CCS[C@]2([H])[C@H](NC(/C(C3=CSC(N)=N3)=N\OC)=O)C1=O)O |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Ceftizoxime is a bacterial inhibitor that works by interfering with bacterial cell wall synthesis and inhibiting the cross-linking of peptidoglycan. |
| Biological Activity | Ceftizoxime是一种细菌抑制剂，其通过干扰细菌细胞壁合成和抑制肽聚糖的交联起作用。[1-2] |
| In Vitro | 头孢唑肟是一种新的肠外头孢菌素衍生物，对头孢菌素和头孢霉素，头孢噻肟，头孢呋辛，头孢噻肟和头孢美唑等头孢菌素和头孢霉素等多种革兰氏阴性杆菌，包括肠杆菌，柠檬酸杆菌和粘质沙雷氏菌等机会性病原体更具活性。头孢唑肟对需氧革兰氏阳性菌和革兰氏阴性菌具有广谱的抗菌活性[1]。 |
| In Vivo | 头孢唑肟对接种小剂量小鼠的治疗效果与头孢噻肟几乎相同[1]。头孢唑肟在生物液体如血清，尿液和组织匀浆中是稳定的，但头孢噻肟在大鼠组织匀浆中是不稳定的。所有物种中头孢唑肟与血清蛋白的结合是所有抗生素中最低的：人类为31％，狗为17％，大鼠为32％[2]。 |
| Animal Experiment | 大鼠[2]本研究中使用的动物包括6周龄雄性JCL：ICR株小鼠，6周龄雄性JCL：SD株大鼠，7.5至15.0公斤雄性比格犬，以及5.8至9.1 -kg雄性恒河猴。注射用头孢唑肟溶于0.9％盐水中。头孢唑肟以20mg / kg的剂量给予所有试验动物。体积为：每只动物通过静脉内(iv)和皮下途径给小鼠0.25mL;通过肌肉内(im)和静脉注射途径给大鼠5mL / kg体重;通过im和iv途径给狗和猴子加入0.5 mL / kg体重[1]。 |
| Data Literature Source | [1]. Kamimura T，et al. Ceftizoxime (Ceftizoxime)，a new parenteral cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother. 1979 Nov;16(5):540-8. [2]. Murakawa T，et al. Pharmacokinetics of ceftizoxime in animals after parenteral dosing. Antimicrob Agents Chemother. 1980 Feb;17(2):157-64 |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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