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My CartCAS：521-74-4
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Yellow to brown Solid
Qty：
Size：
| CAS | 521-74-4 |
| Name | Broxyquinoline |
| Molecular Formula | C9H5Br2NO |
| Molecular Weight | 302.95 |
| Solubility | Soluble in DMSO ≥1mg/mL;Soluble in Water ＜ 0.1mg/mL |
| Purity | ≥98% |
| Appearance | Yellow to brown Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-317-8 |
| MDL | MFCD00006785 |
| SMILES | OC1=C2N=CC=CC2=C(Br)C=C1Br |
| InChIKey | ZDASUJMDVPTNTF-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H5Br2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H |
| PubChem CID | 2453 |
| Target Point | Parasite |
| Passage | Anti-infection |
| Background | Broxyquinoline is an antiprotozoal compound. |
| Biological Activity | Broxyquinoline (Dibromohydroxyquinoline) is a potent severe fever with thrombocytopenia syndrome virus (SFTSV) inhibitor with an IC50 of 5.8 μM. Broxyquinoline is an antiprotozoal agent[1-2]. |
| In Vitro | Four compounds displayed efficacies against parasite growth in vitro with low micromolar IC(50)values. The effective compounds were broxyquinoline(IC(50)64.9 μM)，cloxyquin(IC(50)25.1 μM)，cloxacillin sodium(IC(50)36.2 μM)and sodium dehydrocholate(IC(50)53.2 μM).[2] |
| Data Literature Source | [1]. Shuofeng Yuan，et al. Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus. Viruses. 2019 Apr 25;11(4):385. [2]. Fritzler JM，et al. Novel anti-Cryptosporidium activity of known drugs identified by high-throughput screening against parasite fatty acyl-CoA binding protein (ACBP). J Antimicrob Chemother. 2012 Mar;67(3):609-17. |
| Unit | Bottle |
| Specification | 100mg 250mg |
是一种抗原虫化合物。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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