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My CartCAS：1611493-60-7
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 1611493-60-7 |
| Name | Bictegravir |
| Molecular Formula | C21H18F3N3O5 |
| Molecular Weight | 449.38 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31536971 |
| SMILES | O=C1N([C@](CC2)([H])C[C@]2([H])O3)[C@@]3([H])CN(C=C(C(NCC(C(F)=CC(F)=C4)=C4F)=O)C5=O)C1=C5O |
| Target Point | HIV-1 integrase |
| Passage | Anti-infection |
| Background | It is a novel and effective HIV-1 integrase inhibitor. |
| Biological Activity | Bictegravir (GS-9883)是一种新型的、有效的HIV-1 integrase抑制剂。[1] |
| In Vitro | Bictegravir exhibits potent and selective in vitro antiretroviral activity in both T-cell lines and primary human T lymphocytes，with 50% effective concentrations ranging from 1.5 to 2.4 nM and selectivity indices up to 8，700 relative to cytotoxicity. Bictegravir inhibits the strand transfer activity with an IC50 of 7.5 ± 0.3 nM. Relative to its inhibition of strand transfer activity，Bictegravir is a much weaker inhibitor of 3'-processing activity of HIV-1 integrase，with an IC50 of 241 ± 51 nM. Bictegravir potently inhibits HIV-1 replication in both MT-2 and MT-4 cells with EC50s of 1.5 and 2.4 nM，respectively，and selectivity indices(50% cytotoxic concentration [CC50]/EC50)of ～6，800 in MT-2 cells and ～1，500 in MT-4 cells[1]. |
| Data Literature Source | [1] Tsiang M，et al. Antimicrob Agents Chemother. 2016，60(12):7 |
| Unit | Bottle |
| Specification | 5mg 10mg |
是一种新型的、有效的HIV-1 integrase抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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