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My CartCAS：166663-25-8
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 166663-25-8 |
| Name | Anidulafungin |
| Molecular Formula | C58H73N7O17 |
| Molecular Weight | 1140.24 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 658-060-4 |
| MDL | MFCD00917070 |
| SMILES | O=C(N1[C@@]([H])([C@H]([C@H](C1)C)O)C(N[C@H](O)[C@H](O)C[C@H](NC(C2=CC=C(C=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)OCCCCC)=O)C(N[C@@]5([H])[C@@H](C)O)=O)=O)[C@]([H])([C@@H](C)O)NC([C@@]([C@@H]([C@@H](O)C6=CC=C(C=C6)O)O)([H])NC([C@]7([H])C[C@H](CN7C5=O)O)=O)=O |
| Target Point | Fungal |
| Passage | Anti-infection |
| Background | Anidulafungin is a derivative of echinocandin with antifungal activity. |
| Biological Activity | Anidulafungin 是一种新型的半合成棘球白素，具有抗真菌 (antifungal) 效力。[1-2] |
| In Vitro | Anidulafungin(LY-303366)对所有白色念珠菌(n = 99)，光滑念珠菌(n = 18)和热带假丝酵母(n = 10)分离株的MIC均≤0.32μg/ mL。 Anidulafungin对曲霉菌种也具有活性(90％的菌株被抑制的最低有效浓度，0.02μg/ mL)(n = 20)，对近平滑念珠菌的活性较低(MIC中90％的菌株被抑制[ MIC90]，5.12μg/ mL)(n = 10)，对新生隐球菌(MIC90>10.24μg/ mL)(n = 15)和B. dermatitidis(MIC90，16μg/ mL)无效(n = 29)氟康唑对3种热带假丝酵母菌株，7株光滑念珠菌和2株克鲁斯念珠菌的MIC均≥16μg/ mL。 Anidulafungin对这12个菌株中的11个的MIC为0.08-0.32mg / mL。第十二菌株是克芜菁菌株(氟康唑MIC，32μg/ mL)，其中Anidulafungin MIC为1.28mg / mL。对于这12种菌株，90％的分离株被抑制的MIC(MIC90)为0.32μg/ mL。其余18株光滑芽孢杆菌分离株和氟利昂霉素分离物的Anidulafungin MIC90(FluconazoleMICs≥8μg/ mL)也为0.32 mg / mL。 Anidulafungin对氟康唑MICs≥16mg/ mL的念珠菌属物种和氟康唑MICs≥8μg/ mL的念珠菌物种具有同样的活性。 Anidulafungin对C. neoformans和B. dermatitidis的活性显著低于对C. albicans，C。glabrata和C. tropicalis的活性。酮康唑和两性霉素B是针对新生隐球菌和皮肤癣菌测试的最活跃的抗真菌剂。 Anidulafungin表现出对Aspergillus物种的有效体外活性，MEC90为0.02μg/ mL。对照菌株酵母分离物中的Anidulafungin的MIC对于白色念珠菌ATCC 90028为0.02μg/ mL，对于C. glabrata ATCC 90030为0.16 mg / mL，对于C. neoformans ATCC 90112为>10.24μg/ mL [1]。用CD101选择的CD101 MIC增加2倍或更多的菌株对于Anidulafungin(ANF)和/或Caspofungin(CSF)的MIC增加至少2倍[2]。 |
| Cell Experiment | CD101(以前的SP 3025，biafungin，AF-025)的库存在使用前在100％DMSO中新鲜制备。比较抗真菌剂Anidulafungin(ANF)，Caspofungin(CSF)和两性霉素B(AMB)也在100％DMSO中制备。根据CLSI指南，通过肉汤微量稀释进行MIC测定，不同的是测试化合物以50倍最终测定浓度配制，并使用100μL测定混合物体积(2μL添加至含有细胞的98μL含肉细胞0.5μL)×103至2.5×103CFU / mL)。所有MIC测定至少运行三次，并显示代表性数据集。在整个研究中通过比较针对AMB，CSF和ANF的WT C.krusei菌株ATCC 6258得到的MIC值与先前报道的CLSI 24-h肉汤微量稀释QC范围来评估质量控制(QC)[2]。 |
| Data Literature Source | [1]. Zhanel GG，et al. In vitro activity of a new semisynthetic echinocandin，LY-303366，against systemic isolates of Candida species，Cryptococcus neoformans，Blastomyces dermatitidis，and Aspergillus species. Antimicrob Agents Chemother. 1997 Apr;41(4):863-5 [2]. Locke JB，et al. Characterization of In Vitro Resistance Development to the Novel Echinocandin CD101 in Candida Species. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6100-7 |
| Unit | Bottle |
| Specification | 5mg 10mg |
是一种echinocandin的衍生物, 具有抗真菌 活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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