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My CartCAS：760981-83-7
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 760981-83-7 |
| Name | Solithromycin |
| Molecular Formula | C43H65FN6O10 |
| Molecular Weight | 845.01 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28411434 |
| SMILES | C[C@]([C@H](OC([C@@](F)(C([C@H](C)[C@H]1O[C@@](O[C@H](C)C[C@@H]2N(C)C)([H])[C@@H]2O)=O)C)=O)CC)(O3)[C@]([C@H](C([C@@H](C[C@@]1(C)OC)C)=O)C)([H])N(CCCCN4C=C(C5=CC(N)=CC=C5)N=N4)C3=O |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | It is a fluoroketolide antibacterial compound. |
| Biological Activity | Solithromycin (CEM-101) is an orally bioavailable， effective antimicrobial agent， with IC50s for inhibition of cell viability， protein synthesis， and growth rate are 7.5 ng/mL， 40 ng/mL， and 125 ng/mL for Streptococcus pneumonia， Staphylococcus aureus， and Haemophilus influenzae， respectively. Solithromycin binds to the large 50S subunit of the ribosome and inhibits protein biosynthesis[1]. |
| IC50 | Macrolide |
| In Vitro | The IC50s values for Solithromycin on TNFα and CXCL8 release are 41.6 μM and 78.2 μM， respectively. Solithromycin markedly reduces MMP9 activity， with an IC50 of 14.9 μM[2].Solithromycin (0-333 μM; 72 hours; U937 and PBMC cells) suppresses lipopolysaccharide-induced TNFα release and phorbol 12-myristate 13-acetate (PMA)-induced matrix metalloproteinase 9 (MMP9) activity， and does not affect cell viability in monocytic U937 and PBMC cells[2]. |
| In Vivo | Solithromycin (100 mg/kg; oral administration; every day; for 8 days; C57BL/6J mice) treatment inhibits inflammatory cells accumulation and pro-MMP9 production in cigarette smoke-exposed mice[2]. |
| Data Literature Source | [1]. Rodgers W，et al. Solithromycin inhibition of protein synthesis and ribosome biogenesis in Staphylococcus aureus，Streptococcus pneumoniae，and Haemophilus influenzae. Antimicrob Agents Chemother. 2013 Apr;57(4):1632-1637. [2]. Kobayashi Y，et al. A novel macrolide solithromycin exerts superior anti-inflammatory effect via NF-κB inhibition. J Pharmacol Exp Ther. 2013 Apr;345(1):76-84. |
| Unit | Bottle |
| Specification | 5mg 10mg 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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