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My CartCAS：917389-32-3
Molecular Formula：C29H28F4N4O4
Molecular Weight：572.55
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
Qty：
Size：
| CAS | 917389-32-3 |
| Name | Letermovir |
| Molecular Formula | C29H28F4N4O4 |
| Molecular Weight | 572.55 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22572725 |
| SMILES | O=C(O)C[C@@H]1N(C2=CC(C(F)(F)F)=CC=C2OC)C(N3CCN(C4=CC=CC(OC)=C4)CC3)=NC5=C1C=CC=C5F |
| Target Point | CMV |
| Passage | Anti-infection |
| Background | Letermovir is a novel CMV inhibitor. |
| Biological Activity | Letermovir (AIC246, MK-8228)是新型的anti-CMV化合物，靶向病毒末端酶复合体，对DNA聚合酶抑制剂具有抗性的病毒也具有活性。[1-2] |
| In Vitro | AIC246能够阻止病毒复制，而不抑制后代巨细胞病毒DNA的合成或病毒蛋白的合成。AIC246是目前有效的抗HCMV(巨细胞病毒)的试剂之一，其在细胞中的EC50值约为5 nM，而选择性指数超过15000[1]。 |
| In Vivo | 在小鼠移植瘤模型中，AIC246处理的实验组小鼠相对安慰剂处理的对照组小鼠，其移植细胞中HCMV效价发生剂量依赖性的降低[2]。 |
| Data Literature Source | [1] Goldner T，et al. J Virol. 2011，85(20):10884-93. [2] Lischka P，et al. Antimicrob Agents Chemother. 2010，54(3):1 |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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