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My CartCAS：78613-38-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 78613-38-4 |
| Name | Amorolfine Hydrochloride |
| Molecular Formula | C21H35NO·HCl |
| Molecular Weight | 353.97 |
| Solubility | Soluble in Water/DMSO ≥1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 689-236-9 |
| MDL | MFCD00903738 |
| SMILES | C[C@@H]1O[C@H](C)CN(CC(C)CC2=CC=C(C(C)(C)CC)C=C2)C1.Cl |
| InChIKey | XZKWIPVTHGWDCF-KUZYQSSXSA-N |
| InChI | InChI=1S/C21H35NO.ClH/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22;/h8-11,16-18H,7,12-15H2,1-6H3;1H/t16?,17-,18+; |
| PubChem CID | 54259 |
| Target Point | Fungal |
| Passage | Anti-infection |
| Background | Amorolfine Hydrochloride is an antifungal compound. |
| Biological Activity | Amorolfine (Ro 14-4767/002) hydrochloride is a potent anti-fungal agent. Amorolfine hydrochloride inhibits ergosterol biosynthesis. Amorolfine hydrochloride has the potential for the research of Neoscytalidium dimidiatum onychomycosis[1][2]. |
| In Vitro | Amorolfine hydrochloride acts primarily by inhibiting ergosterol biosynthesis， a component of fungal cell membrane， and possesses both fungistatic and fungicidal activity[1].Amorolfine hydrochloride (0-128 mg/l) (2-7 days) shows anti-fungal activity for Dermatophyte fungi， Filamentous fungi， Pathogenic yeasts， Dimorphic fungi， Dematiaceous fungi[1].Amorolfine hydrochloride shows anti-fungal activity with 90% killing corresponding concentrations of 3， 3， 10 and 100 mg/L for Trichophyton mentagrophytes， C. albicans， Histoplasma capsulatum， Cryptococcus neoformans， respectively[1]. |
| In Vivo | Amorolfine hydrochloride (0.01%-1%; Intravaginal application; twice daily for 3 days) shows anti-fungal activity in rats with vaginal candidiasis[1]. |
| Data Literature Source | [1]. Haria M，et al. Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections. Drugs. 1995 Jan;49(1):103-20. [2]. Bunyaratavej S，et al. Efficacy of 5% amorolfine nail lacquer in Neoscytalidium dimidiatum onychomycosis. J Dermatolog Treat. 2016 Aug;27(4):359-63. |
| Unit | Bottle |
| Specification | 50mg 10mM*1mL in Water 100mg 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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