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My CartCAS：156-86-5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 156-86-5 |
| Name | H-HoArg-OH |
| Molecular Formula | C7H16N4O2 |
| Molecular Weight | 188.23 |
| Solubility | Soluble in Water ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00237108 |
| SMILES | [H][C@](N)(CCCCNC(N)=N)C(O)=O |
| InChIKey | QUOGESRFPZDMMT-YFKPBYRVSA-N |
| InChI | InChI=1S/C7H16N4O2/c8-5(6(12)13)3-1-2-4-11-7(9)10/h5H,1-4,8H2,(H,12,13)(H4,9,10,11)/t5-/m0/s1 |
| PubChem CID | 9085 |
| Target Point | alkaline phosphatase |
| Passage | Metabolic Enzyme&Protease |
| Background | It is an organ-specific, non-competitive inhibitor of alkaline phosphohydrolases. |
| Biological Activity | H-HoArg-OH，精氨酸的同系物，是人骨和肝脏碱性磷酸酶 (alkaline phosphatase) 的强效抑制剂。[1-2] |
| In Vitro | 发现H-HoArg-OH(L-高精氨酸)是精氨酸的同源物，是人体骨骼和肝脏碱性磷酸酶的强抑制剂，与H-HoArg-OH不同，它对肠道和胎盘碱性磷酸酶几乎没有影响。抑制肠道和胎盘碱性磷酸酶，但不抑制肝脏和骨骼酶。提到的这四种组织是血清碱性磷酸酶的主要贡献者[1]。还表明低水平的内源氨基酸H-HoArg-OH与心血管疾病有关[2]。 |
| Data Literature Source | [1]. Fishman W，et al. L-homoarginine; an inhibitor of serum 'bone and liver' alkaline phosphatase. Clin Chim Acta. 1970 Aug;29(2):339-41. [2]. Atzler D，et al. L-homoarginine and cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):83-8 |
| Unit | Bottle |
| Specification | 100mg |
是一种具有器官特异性、非竞争性的碱性磷酸水解酶（alkaline phosphohydrolases）抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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