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My CartCAS：339-72-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 339-72-0 |
| Name | L-Cycloserine |
| Molecular Formula | C3H6N2O2 |
| Molecular Weight | 102.09 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 206-427-0 |
| MDL | MFCD00064324 |
| SMILES | O=C1NOC[C@@H]1N |
| Target Point | 3-ketodihydrosphingosine synthetase，GABA pyridoxal 5′-phosphate-dependent aminitransferase |
| Passage | Others |
| Background | L-cycloserine irreversibly inhibits GABA 5-phosphate pyridoxal aminotransferase. Also inhibits 3-ketodihydrosphingosine synthase. |
| Biological Activity | L-Cycloserine (Levcycloserine， Levcicloserina， Levcycloserinum， (-)-Cycloserine， (S)-Cycloserine) is a potent inhibitor of the sphingolipid pathway via inhibiting 3-ketodihydrosphingosine synthetase.[1-3] |
| In Vitro | L-Cycloserine is a potent inhibitor of the first en zyme of the sphingolipid pathway，3-ketodihydrosphin-gosine(3KDS)synthase(serine palmitoyltransferase)and causes an irreversible inhibition of 3KDS synthase derived from a bacterial source(Bacteroides levii)and from brain and heart microsomes in vitro[3]. |
| In Vivo | Long-term administration of a low dosage of L-cycloserine subcutaneously to mice results in a significant reduction in the level of brain cerebrosides with little effect on other sphingolipids[3]. |
| Data Literature Source | [1] Williams RD，et al. J Lipid Res. 1987，28(12):1478-81. [2] Sundaram KS，et al. Antimicrob Agents Chemother. 1984，26(2):211-3. [3] Sundaram KS，et al. Neurochem Res. 1989，14(3):245-8. |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
L-cycloserine不可逆地抑制GABA 5'-磷酸吡哆醛氨基转移酶。还可以抑制3-酮二氢鞘氨醇合成酶。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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