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My CartCAS：302-84-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 302-84-1 |
| Name | DL-Serine |
| Molecular Formula | C3H7NO3 |
| Molecular Weight | 105.09 |
| Solubility | Soluble in Water ≥30mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 206-130-6 |
| MDL | MFCD00064223 |
| SMILES | NC(CO)C(O)=O |
| InChIKey | MTCFGRXMJLQNBG-UHFFFAOYSA-N |
| InChI | InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7) |
| PubChem CID | 617 |
| Target Point | Others |
| Passage | Others |
| Background | It is a mixture of D-serine and L-serine. |
| Biological Activity | Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2.[1-2] |
| In Vitro | The non-essential amino acid serine supports several metabolic processes that are crucial for the growth and survival of proliferating cells，including protein，amino acid and glutathione synthesis. As an important one-carbon donor to the folate cycle，serine contributes to nucleotide synthesis，methylation reactions and the generation of NADPH for antioxidant defence[2]. Serine activates recombinant PKM2 with a half maximal activation concentration(AC50)of 1.3 mM. Isothermal titration calorimetry was used to determine the dissociation constant(Kd)of the PKM2-serine interaction as 0.20 mM. Serine can bind to and activate human PKM2 and that following serine deprivation，PKM2 activity in cells is reduced. This reduction in PKM2 activity shifts cells to a fuel-efficient mode where more pyruvate is diverted to the mitochondria and more glucose derived carbon is channelled into serine biosynthesis to support cell proliferation[1]. |
| Data Literature Source | [1] Chaneton B，et al. Nature. 2012，491(7424):458-462. [2] Yang M，et al. Nat Rev Cancer. 2016，16(10):650-62. |
| Unit | Bottle |
| Specification | 100mg 250mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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