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My CartCAS：1628316-74-4
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1628316-74-4 |
| Name | MI136 |
| Molecular Formula | C23H21F3N6S |
| Molecular Weight | 470.51 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | FC(F)(F)CC(S1)=CC2=C1N=CN=C2NC3CCN(CC4=CC=C(NC(C#N)=C5)C5=C4)CC3 |
| Target Point | Androgen Receptor |
| Passage | Endocrinology & Hormones |
| Background | MI-136 inhibits DHT-induced expression of androgen receptor (AR)-targeted genes. |
| Biological Activity | MI-136抑制DHT所诱导的雄激素受体(AR)靶向基因的表达。[1] |
| In Vitro | AR阳性细胞系如VCaP，LNCaP and 22RV1对MI-136具有敏感性，进行MI-136的处理会抑制在AR刺激后与ASH2L结合的基因的表达、诱导VCaP细胞的凋亡，在AR依赖性细胞系(LNCaP和VCaP)中阻止DHT诱导的细胞增殖。MI-136对细胞增殖的作用类似于MDV-310(第二代FDA认证的抗雄激素药物，用于治疗难治性前列腺癌)[1] |
| In Vivo | 对携有VCaP肿瘤的小鼠施以MI-136(40mg/kg)，肿瘤体积明显减小，但对小鼠体重没有影响[1]。 |
| Cell Experiment | Animal Models: VCaP荷瘤小鼠(VCaP异种移植); Dosages: 40 mg/kg; Administration: 腹膜腔内注射[1] |
| Animal Experiment | 为了检测MI-136对AR信号的效果，VCaP细胞用DMSO或5 μM MI-136处理了48小时。经过血清饥饿后，用10 nM DHT刺激细胞，12小时。然后提取RNA进行表达分析。[1] |
| Data Literature Source | [1] Malik R，et al. Nat Med. 2015，21(4):344-352. |
| Unit | Bottle |
| Specification | 5mg 10mg |
MI-136抑制DHT所诱导的雄激素受体(AR)靶向基因的表达。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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