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My CartCAS：603-00-9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 603-00-9 |
| Name | Proxyphylline |
| Molecular Formula | C10H14N4O3 |
| Molecular Weight | 238.24 |
| Solubility | Soluble in DMSO ≥2mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 210-028-7 |
| MDL | MFCD00022833 |
| SMILES | O=C(N1C)N(C)C2=C(N(CC(O)C)C=N2)C1=O |
| InChIKey | KYHQZNGJUGFTGR-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3 |
| PubChem CID | 4977 |
| Target Point | Adenosine Receptor |
| Passage | GPCR & G Protein |
| Background | It can selectively antagonize A1 adenosine receptors. |
| Biological Activity | Proxyphylline是一种甲基黄嘌呤衍生物，临床上作为心脏兴奋剂，血管扩张剂和支气管扩张剂使用。[1-3] |
| In Vitro | Proxyphylline已显示出血管扩张和心脏刺激作用。 Proxyphylline产生与确定的正性肌力作用相关的冠状动脉血流增加[1]。 Proxyphylline抑制气管PDE活性，100μg/ mL代谢茶碱可获得气管平滑肌的半最大松弛[2] |
| In Vivo | 在一项双盲交叉研究中，proxyphylline表现出支气管扩张作用[3]。 Proxyphylline抑制人肺组织中的cAMP和cGMP水解。在低cAMP浓度下，代谢茶碱的表观抑制常数为0.06-0.7mM，在高cAMP浓度下为1.0mM [3]。 |
| Data Literature Source | [1]. Takeda K，et al. Effects of aminophylline，proxyphylline and a proxyphylline-Melilotus extract-rutin mixture(theoesberiven) on the heart and the coronary circulation. Jpn J Pharmacol. 1977 Oct;27(5):709-20. [2]. Kukovetz WR，et al. Overadditive synergism between theophylline，diprophylline and proxyphylline in tracheal smooth muscle relaxation. Arzneimittelforschung. 1983;33(10):1450-4. [3]. Rasmussen FV，et al. Pharmacokinetics and bronchodilatory effect of proxyphylline and theophylline. Eur J Respir Dis. 1984 Jan;65(1):20-7 |
| Unit | Bottle |
| Specification | 500mg 1g |
能够选择性地拮抗A1 adenosine receptors。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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