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My CartCAS：500-66-3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 500-66-3 |
| Name | Olivetol |
| Molecular Formula | C11H16O2 |
| Molecular Weight | 180.24 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-908-8 |
| MDL | MFCD00002293 |
| SMILES | OC1=CC(CCCCC)=CC(O)=C1 |
| InChIKey | IRMPFYJSHJGOPE-UHFFFAOYSA-N |
| InChI | InChI=1S/C11H16O2/c1-2-3-4-5-9-6-10(12)8-11(13)7-9/h6-8,12-13H,2-5H2,1H3 |
| PubChem CID | 10377 |
| Target Point | Cytochrome P450，Cannabinoid Receptor（CB1，CB2，CYP1A1，CYP2C19） |
| Passage | GPCR & G Protein;Neuronal Signaling;Metabolic Enzyme&Protease |
| Background | Olivetol is a polyphenolic compound found in lichens or produced by some insects. Olivetol competitively inhibits the cannabinoid receptors CB1 and CB2, and inhibits the activity of CYP2C19 and CYP2D6. |
| Biological Activity | Olivetol 是一种天然多酚类化合物，存在于地衣中，或由一些昆虫产生[3]。Olivetol 竞争性地抑制大麻素受体 CB1 和 CB2，抑制 CYP2C19 和 CYP2D6 的活性，IC50 值和 Ki 值分别为 15.3 μM, 7.21 μM 和 2.71 μM, 2.87 μM[1][2]。 |
| IC50 | 15.3μM(CYP2C19)[1];7.21μM(CYP2D6)[2] |
| In Vitro | Olivetol抑制CYP2C19活性的(S)- mephenytoin 4'-羟化酶活性，IC50为15.3μM，Ki为2.71μM[1]。 Olivetol还抑制重组CYP2D6的AMMC O-去甲基化酶活性，IC50为7.21μM，Ki为2.87μM[2]。 Olivetol是大麻素受体CB1和CB2的竞争性抑制剂[3]。 |
| Data Literature Source | [1]. Jiang R，et al. Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Drug Metab Pharmacokinet. 2013;28(4):332-8. [2]. Yamaori S，et al. Cannabidiol，a major phytocannabinoid，as a potent atypical inhibitor for CYP2D6. Drug Metab Dispos. 2011 Nov;39(11):2049-56. [3]. James J. Carberry ，et al. Composition of Olivetol and Method of Use to Reduce or Inhibit the Effects of Tetrahydrocannabinol in the Human Body. US20170143644A1 |
| Unit | Bottle |
| Specification | 100mg |
Olivetol 是一种多酚类化合物，存在于地衣中，或由一些昆虫产生。Olivetol 竞争性地抑制大麻素受体 CB1 和 CB2，抑制 CYP2C19 和 CYP2D6 的活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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