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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > L-Noradrenaline BitartrateCAS：108341-18-0
Molecular Formula：C8H11NO3·C4H6O6·H2O
Molecular Weight：337.28
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 108341-18-0 |
| Name | L-Noradrenaline Bitartrate |
| Molecular Formula | C8H11NO3·C4H6O6·H2O |
| Molecular Weight | 337.28 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 627-941-5 |
| MDL | MFCD00150449 |
| SMILES | OC1=CC=C([C@@H](O)CN)C=C1O.O=C(O)[C@H](O)[C@@H](O)C(O)=O.O |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein;Neuronal Signaling |
| Background | L-Noradrenaline Bitartrate is a β1-selective adrenergic receptor agonist. |
| Biological Activity | Norepinephrine bitartrate monohydrate 是β1-选择性的肾上腺素能受体激动剂，EC50 为 5.37 μM。[1-2] |
| IC50 | EC50: 5.37μM(β1-selective adrenergic receptor)[1] |
| In Vitro | 去甲肾上腺素(NE)酒石酸氢盐一水合物通常被认为是β1亚型选择性肾上腺素能激动剂。去甲肾上腺素(NE)在β2-肾上腺素能受体中也具有更高浓度的直接活性[1]。从新生儿野生型C57BL / 6J小鼠中分离来自腹股沟脂肪垫(iWA)或肩胛间脂肪垫(BA)的脂肪细胞并进行培养。为了检查激活AT2对β-肾上腺素能信号传导的影响，首先评估cAMP产生以响应去甲肾上腺素(NE，10μM)，有或没有CGP(10nM)共处理。去甲肾上腺素(NE)如iWA中预期的那样增加cAMP，并且CGP不会改变这种效应。还已知去甲肾上腺素(NE)诱导脂解，并且需要释放的脂肪酸来功能性激活UCP1蛋白并刺激产热。在去甲肾上腺素(NE)治疗后，Ser133处的CREB磷酸化增加，并且在小鼠iWA中通过CGP共处理显著减弱[2]。 |
| Cell Experiment | 来自38岁非糖尿病女性供体的皮下前脂肪细胞用TERT和HPV E6 / E7永生化。对于目前的研究，通过环克隆分离具有一致分化能力的稳定二倍体克隆(称为克隆B)。细胞在前脂肪细胞PGM2培养基中生长。一旦细胞汇合，通过在由地塞米松，IBMX，吲哚美辛和另外的胰岛素组成的分化培养基中孵育诱导分化。细胞分化10天。在处理之前，将培养基替换为PGM2培养基一天，然后切换至无血清培养基过夜进行处理。用载体，去甲肾上腺素(NE，10μM)，CGP(10nM)或去甲肾上腺素(NE)和CGP [2]处理脂肪细胞6小时。 |
| Data Literature Source | [1]. MacGregor DA，et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [2]. Littlejohn NK，et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. |
| Unit | Bottle |
| Specification | 200mg 500mg 1g |
是β1-选择性的肾上腺素能受体激动剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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