{{cart_num}}
My CartCAS：666260-75-9
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 666260-75-9 |
| Name | GW-842166 |
| Molecular Formula | C18H17Cl2F3N4O2 |
| Molecular Weight | 449.25 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-258-5 |
| SMILES | ClC1=CC(Cl)=C(NC2=NC=C(C(NCC3CCOCC3)=O)C(C(F)(F)F)=N2)C=C1 |
| Target Point | Cannabinoid Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | GW-842166 is a potent and selective cannabinoid receptor 2 activator. |
| Biological Activity | GW842166X是有效，选择性的 cannabinoid receptor 2 激活剂，IC50 值为63 nM。[1] |
| IC50 | 63nM(human CB2);91nM(rat CB2)[1] |
| In Vitro | GW842166X对大鼠和人重组CB2受体显示出相似的效力和功效。在人和大鼠CB1重组试验中，它在高达30μM的浓度下没有显著的激动剂活性[1]。 |
| In Vivo | GW842166X在炎性疼痛的大鼠FCA模型中具有0.1mg / kg的口服ED50，并且显示0.3mg / kg的痛觉过敏完全逆转。在给药后1小时，实验中GW842166X的血液浓度为30nM(0.03mg / kg)，130nM(0.1mg / kg)和370nM(0.3mg / kg)。在FCA模型中给药4天后，相对于第1天在第4天未观察到抗痛觉过敏反应的统计学差异，表明不发生耐受[1]。 |
| Data Literature Source | [1]. Giblin GM，et al. Discovery of 2-[(2，4-dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide，a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007 May 31;50(11):2597-600 |
| Unit | Bottle |
| Specification | 5mg 10mg |
是有效，选择性的 cannabinoid receptor 2 激活剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
