{{cart_num}}
My CartCAS：913358-93-7
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 913358-93-7 |
| Name | Almorexant Hydrochloride |
| Molecular Formula | C29H31F3N2O3·HCl |
| Molecular Weight | 549.02 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01646135 |
| SMILES | CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O.Cl |
| Target Point | Orexin Receptor (OX Receptor) |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | Almorexant Hydrochloride is a potent orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist. |
| Biological Activity | Almorexant HCl (ACT-078573)是口服有效的双重orexin receptor 拮抗剂，其作用于受体 OX1 和 OX2 的 IC50 分别为 6.6 nM 和 3.4 nM。[1-3] |
| IC50 | OX2 receptor: 3.4nM;OX1 receptor: 6.6nM[1] |
| In Vitro | Almorexant抑制10 nM人食欲肽-A诱导的细胞内Ca2+的增加，在中国仓鼠卵巢细胞中，对OX1受体的IC50为16 nM(大鼠)和13 nM(人)，对OX2受体的IC50为15 nM(大鼠)和8 nM(人)。[1] |
| In Vivo | Almorexant(300毫克/千克，口服)降低雄性Wistar大鼠的警觉，并增加其非REM和REM睡眠期的电生理学指标。在狗体内，Almorexant(100 毫克/千克，口服)引起嗜睡，并增加REM睡眠的替代标志。[1] Almorexant诱导强的抗抑郁样作用和独立于神经作用与压力相关的下丘脑缺陷的恢复。[2]此外，Almorexant也能降低乙醇自身给药，在高饮用啮齿动物模型中。[3] |
| Data Literature Source | [1] Brisbare-Roch C，et al. Nat Med. 2007，13(2)，150-155. [2] Nollet M，et al. Neuropsychopharmacology. 2012，37(10)，2210-2221. [3] Anderson RI，et al. Front Neurosci. 2014，8，33. |
| Unit | Bottle |
| Specification | 5mg |
是一种有效的orexin 1 receptor (OX1)/orexin 2 receptor (OX2) 拮抗剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
