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My Cart> Cell Biology > Cell Detection > Cell Growth Factor > Recombinant Human Cyclin-H/CCNH
Purity：≥95% as determined by reducing SDS-PAGE.
Storage：Store at≤-70℃，6 months.with seal;3 month after opening.Avoid freeze/thaw cycles.
Appearance：Supplied as a 0.2 μm filtered solution of 20mM Tris,100mM NaCl,2mM EDTA,2mM DTT,30%Glycerol,pH8.5.
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| Appearance | Supplied as a 0.2 μm filtered solution of 20mM Tris,100mM NaCl,2mM EDTA,2mM DTT,30%Glycerol,pH8.5. |
| Purity | ≥95% as determined by reducing SDS-PAGE. |
| Storage | Store at≤-70℃，6 months.with seal;3 month after opening.Avoid freeze/thaw cycles. |
| Background | Human CCNH，also known as Cyclin-H，MO15-associated protein，p34 and p37，is a protein which belongs to the highly conserved cyclin family.Cyclin family members are characterized by a dramatic periodicity in protein abundance through the cell cycle.Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event.This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1.CCNH regulates CDK7 which is the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex.CAK activates the cyclin-associated kinases CDK1，CDK2，CDK4 and CDK6 by threonine phosphorylation.CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A)，allowing its escape from the promoter and elongation of the transcripts.CCNH is also involved in cell cycle control and in RNA transcription by RNA polymerase II.Its expression and activity are constant throughout the cell cycle. |
| Source | E.coli |
| Endotoxin | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| Unit | Piece |
| Specification | 10ug 50ug 500ug 1mg |
Cell growth factor
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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