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My Cart> Cell Biology > Cell Detection > Cell Growth Factor > Recombinant Human Mothers Against Decapentaplegic Homolog 2/SMAD2
Purity：≥95% as determined by reducing SDS-PAGE.
Storage：Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months.
Appearance：Lyophilized from a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, pH 7.4.
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| Appearance | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, pH 7.4. |
| Purity | ≥95% as determined by reducing SDS-PAGE. |
| Storage | Powder:＜-20℃ for long store;RT，3 weeks.Liquid:4-7℃，2-7 days;＜-20℃，3 months. |
| Background | Mothers against decapentaplegic homolog 2(SMAD2) is a cytoplasm protein which belongs to the dwarfin/SMAD family.Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus.Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases.SMAD2 is contains 1 MH1 (MAD homology 1) domain and1 MH2 (MAD homology 2) domain.It is expressed at high levels in skeletal muscle，endothelial cells，heart and placenta.It binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and，on formation of the SMAD2/SMAD4 complex，activates transcription.It may act as a tumor suppressor in colorectal carcinoma.And SMAD2 positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
| Source | E.coli |
| Solvent | Always centrifuge tubes before opening.Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Endotoxin | Less than 0.1 ng/ug(1 EU/ug)as determined by LAL test. |
| Unit | Piece |
| Specification | 10ug 50ug 500ug 1mg |
Cell growth factor
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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