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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > AbrocitinibCAS：1622902-68-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1622902-68-4 |
| Name | Abrocitinib |
| Molecular Formula | C14H21N5O2S |
| Molecular Weight | 323.41 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CN([C@H]1C[C@@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2 |
| Target Point | JAK，TYK2 |
| Passage | JAK/STAT Signaling |
| Background | Abrocitinib is a novel, potent JAK1 inhibitor |
| Biological Activity | Abrocitinib (PF-04965842) is a potent， orally active and selective JAK1 inhibitor， with IC50s of 29 and 803 nM for JAK1 and JAK2， respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50， 1.253 μM)， and inhibits phosphorylation of STAT1， STAT3 and STAT5 after stimulation. Effective in autoimmune disease[1]. |
| In Vitro | Abrocitinib(Compound 25)inhibits IFNα-stimulated phosphorylation of STAT3，IFN-stimulated phosphorylation of STAT1 in human whole blood(HWB)，as well as pSTAT5 in CD34+ spiked into HWB(JAK2)，with IC50s of 189，163 nM，7.178 μM，respectively[1]. |
| In Vivo | Abrocitinib(Compound 25; 5，15，50 mg/kg，p.o.，daily for 7 days)significantly reduces paw swelling in rat adjuvant-induced arthritis model[1]. |
| Data Literature Source | [1]. Vazquez ML，et al. Identification of N-{cis-3-[Methyl(7H-pyrrolo[2，3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. J Med Chem. 2018 Feb 8;61(3):1130-115 |
| Unit | Bottle |
| Specification | 2mg |
是一种新型，有效的JAK1抑制剂
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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