Pyridoxal Phosphate
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Cat.No：IP3540 Solarbio
CAS：54-47-7
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：Light yellow to yellow Solid
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Inhibitors & Antagonists & Agonists
PI3K/Akt/mTOR
Endocrinology & Hormones
Protein Tyrosine Kinase/PTK
Angiogenesis
HIF
Immunology & Inflammation
Stem Cells
Apoptosis
Metabolic Enzyme & Protease
Autophagy
ER Stress
Cell Cycle
Cytoskeleton
DNA Damage & DNA Repai
Epigenetics
Ubiquitin
JAK/STAT
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MAPK
NF-κB
Membrane Transporter & Ion Channel
TGF-β/Smad
Hippo
Antibody-drug Conjugate/ADC Related
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Pipette & Dispenser & Pipette Dispensing Instrument
Oscillating Mixing & Stirring & Dispersing Instrument
Temperature Control & Sampling & Grinding Crushing Instrument
Sterilization & Filtration Instruments
PCR Instrument & Light Glue Instrument
Spectrophotometer
Centrifuge
Shaker
Vacuum Pump
Other Small Instruments
Product Information
| CAS | 54-47-7 |
| Name | Pyridoxal Phosphate |
| Molecular Formula | C8H10NO6P |
| Molecular Weight | 247.14 |
| Solubility | Soluble in Water ≥10mg/mL(Need to add HCl/NaOH dropwise to help dissolve) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years |
| EC | EINECS 200-208-3 |
| MDL | MFCD00006333 |
| SMILES | O=CC1=C(O)C(C)=NC=C1COP(O)(O)=O |
| InChIKey | NGVDGCNFYWLIFO-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) |
| PubChem CID | 1051 |
| Passage | Others |
| Background | Pyridoxal Phosphate is the active form of vitamin B6 and acts as a coenzyme in all transamination reactions as well as in the decarboxylation, deamination and racemization of certain amino acids. |
| Biological Activity | Pyridoxal phosphate 是维生素 B6 的活性形式，可以抑制 reverse transcriptases 的活性，用于迟发性运动障碍症的研究。[1-2] |
| In Vitro | 吡哆醛5'-磷酸盐严重抑制DNA聚合酶和RNase H.磷酸吡哆醛导致DNA合成速率的模拟降低[1]。与磷酸吡哆醛的缀合完全抑制NEIL2。在广泛的酶/底物比例范围内，吡哆醛磷酸盐缀合的NEIL2显示出比完整酶低得多的活性。磷酸吡哆醛结合后，NEIL2结合THF配体的能力完全丧失[2]。 |
| Data Literature Source | [1]. Modak MJ. Pyridoxal 5' phosphate: a selective inhibitor of oncornaviral DNA polymerases. Biochem Biophys Res Commun. 1976 Jul 12;71(1):180-7. [2]. Grin IR，et al. Inactivation of NEIL2 DNA glycosylase by pyridoxal phosphate reveals a loop important for substrate binding. Biochem Biophys Res Commun. 2010 Mar 26;394(1):100-5 |
| Unit | Bottle |
| Specification | 50mg 100mg 500mg 1g |
是维生素B6的活性形式，在所有氨基转移反应以及某些氨基酸的脱羧，脱氨和外消旋反应中均充当辅酶。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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