{{cart_num}}
My CartCAS：1021868-92-7
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
Qty：
Size：
| CAS | 1021868-92-7 |
| Name | ZM-39923 Hydrochloride |
| Molecular Formula | C23H26ClNO |
| Molecular Weight | 367.91 |
| Solubility | Soluble in DMSO ≥2mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD04974534 |
| SMILES | O=C(C1=CC=C2C=CC=CC2=C1)CCN(C(C)C)CC3=CC=CC=C3.[H]Cl |
| Target Point | EGFR，JAK，TGM2 |
| Passage | Angiogenesis;Protein Tyrosine Kinase/RTK; JAK/STAT Signaling |
| Background | ZM39923 hydrochloride is a JAK3 inhibitor that also inhibits tissue-type transglutaminase (TGM2) activity. |
| Biological Activity | ZM39923 hydrochloride 是一种 JAK3 抑制剂， pIC50 值为 7.1；ZM39923 hydrochloride 同时可抑制组织型转谷氨酞胺酶 (TGM2) 的活性，IC50 值为 10 nM。[1-3] |
| In Vitro | ZM39923盐酸盐是JAK3抑制剂，pIC50为7.1。 ZM39923(化合物7)显示对EGF-R和JAK1的弱抑制作用(分别为pIC50，5.6，4.4)，并且不显着抑制酪氨酸激酶Lck和CDK4(pIC50 <5.0)[1]。 ZM39923有效抑制组织转谷氨酰胺酶(TGM2)，IC50为10 nM，直接作用于纯化的TGM2，抑制Ca2 +激活形式的TGM2 [2]。 ZM39923阻断由CCL19诱导的JAK3的磷酸化，并且这种作用类似于CCR7抗体的作用。 ZM39923还显着阻断CCL19诱导的伤口闭合率，并减少PCI-37B细胞的迁移和侵袭[3]。 |
| Cell Experiment | 将PCI-37B(表达CCR7的转移性SCCHN细胞系)细胞在含有10％胎牛血清，青霉素和链霉素的Dulbecco改良的Eagle培养基(DMEM)中在5％CO 2和95％空气中于37℃培养。使用细胞计数试剂盒-8 [3]测定剂量的ZM39923抑制剂治疗。 |
| Data Literature Source | [1]. Brown GR，et al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9. [2]. Lai TS，et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol. 2008 Sep 22;15(9):969-78. [3]. Zhang Z，et al. Jak3 is involved in CCR7-dependent migration and invasion in metastatic squamous cell carcinoma of the head and neck. Oncol Lett. 2017 May;13(5):3191-3197 |
| Unit | Bottle |
| Specification | 5mg 10mg |
ZM39923 hydrochloride 是一种 JAK3 抑制剂，同时可抑制组织型转谷氨酞胺酶 (TGM2) 的活性。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
