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My CartCAS：1883429-22-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 1883429-22-8 |
| Name | BI-9564 |
| Molecular Formula | C20H23N3O3 |
| Molecular Weight | 353.41 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30182324 |
| SMILES | CN(C)CC1=CC(OC)=C(C(C2=C3C=NC=C2)=CN(C)C3=O)C=C1OC |
| Target Point | BRD9，BRD7，CECR2，Epigenetic Reader Domain |
| Passage | Epigenetics |
| Background | BI-9564 is a selective bromodomain protein inhibitor of BRD9 and BRD7. |
| Biological Activity | BI-9564是一种选择性BRD9和BRD7的溴结构域蛋白抑制剂，IC50分别为75 nM和3.4 μM。[1] |
| In Vitro | BI-9564能够选择性抑制绝大多数AML细胞系的生长[1]。 |
| Cell Experiment | 在密度为750，000个MV-4-11个细胞/孔中加入含不同浓度化合物的生长培养基(IMDM，10 % FBS，GlutaMAX，25 mM HEPES 和 0，1% 2-Mercaptoethanol)。孵育2小时后，离心收集细胞，用预冷的PBS进行洗涤，加入15 μl细胞提取缓冲对细胞进行裂解，冰上放置30分钟，用声波讲解法将核酸打断。[1] |
| Animal Experiment | Animal Models: CIEA-NOG雌性小鼠; Dosages: 10 mL/kg; Administration: 口服[1] |
| Data Literature Source | [1] Martin LJ，et al. J Med Chem. 2016，59(10):4462-75. |
| Unit | Bottle |
| Specification | 5mg 10mg |
BI-9564是一种选择性BRD9和BRD7的溴结构域蛋白抑制剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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