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My CartCAS：1982372-88-2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to brown Solid
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| CAS | 1982372-88-2 |
| Name | A-196 |
| Molecular Formula | C18H16Cl2N4 |
| Molecular Weight | 359.25 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD29924807 |
| SMILES | ClC1=C(Cl)C=C(C(C2=CC=NC=C2)=NN=C3NC4CCCC4)C3=C1 |
| Target Point | SUV420H1，SUV420H2 |
| Passage | Epigenetics |
| Background | A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2. |
| Biological Activity | A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 with IC50 values of 25 nM and 144 nM， respectively. A-196 inhibits SUV4-20 biochemically in a substrate-competitive manner. A-196 represents a first-in-class chemical probe of SUV4-20 to investigate the role of histone methyltransferases in genomic integrity[1]. |
| IC50 | IC50: 25nM(SUV420H1) and 144nM(SUV420H2)[1]. |
| In Vitro | A-196(0-5 μM; 48 hours; U2OS cells)treatment results in an increase in H4K20me1(EC50 value of 735 nM)and a decrease in both H4K20me2 and H4K20me3(EC50 values of 262 and 370 nM，respectively)[1].A-196(10 μM; 72 hours; Wild-type，Suv4-20h double knockout and inhibitortreated mouse embryonic fibroblast cells)inhibits both SUV4-20 enzymes in cells in multiple tissue types without overt toxicity[1]. |
| Data Literature Source | [1]. Bromberg KD，et al. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol. 2017 Mar;13(3):317-324. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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