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My CartCAS：256925-03-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
Qty：
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| CAS | 256925-03-8 |
| Name | AL-082D06 |
| Molecular Formula | C30H38N8O2 |
| Molecular Weight | 409.91 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00100145 |
| SMILES | O=[N+](C1=CC=C(Cl)C(C(C2=CC=C(N(C)C)C=C2)C3=CC=C(N(C)C)C=C3)=C1)[O-] |
| Target Point | Glucocorticoid Receptor |
| Passage | GPCR & G Protein |
| Background | AL082D06 is a non-steroidal glucocorticoid receptor antagonist. |
| Biological Activity | AL 082D06 is a selective, nonsteroidal glucocorticoid receptor (GR) antagonist with Ki of 210 nM.[1] |
| IC50 | Ki: 210nM(GR)[1] |
| In Vitro | AL 082D06(D06)binds specifically to GR with nanomolar affinity. Addition of AL 082D06 causes a dose-dependent decrease in transcriptional activation from the MMTV:Luc reporter stimulated with half-maximal DEX concentrations. AL 082D06 acts to antagonize reporter activity using several glucocorticoid-responsive promoter- reporter systems including the 3-kb tyrosine amino transferase(TAT)promoter and less complex promoters comprised of isolated glucocorticoid response element(GRE)sequences. AL 082D06 competes with 3H-Dex for baculovirus-expressed GR with nanomolar affinity. Other intracellular receptors(AR，ER，PR，and MR)have no affinity for AL 082D06 in a similarly structured binding assay with the appropriate receptor and tritiated ligand(>2500 nM). AL 082D06 has no activation efficacy on the progesterone，androgen，mineralocorticoid，retinoid，glucocorticoid，or estrogen receptors. AL 082D06 is very efficacious at antagonizing GR activity but exhibits much weaker efficacy when tested against the other steroid receptors in contrast to the reference antagonists used as controls[1]. |
| Data Literature Source | [1]. Miner JN，et al. A nonsteroidal glucocorticoid receptor antagonist. Mol Endocrinol. 2003 Jan;17(1):117-27. |
| Unit | Bottle |
| Specification | 2mg |
AL082D06是非类固醇的糖皮质激素受体拮抗剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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