{{cart_num}}
My CartCAS：427-51-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 427-51-0 |
| Name | Cyproterone Acetate |
| Molecular Formula | C24H29ClO4 |
| Molecular Weight | 416.94 |
| Solubility | Soluble in DMSO≥10mg/mL；Soluble in Ethanol≥1mg/mL；Soluble in Water＜1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-048-3 |
| MDL | MFCD00192402 |
| SMILES | C[C@@]12C(C(Cl)=C[C@]3([H])[C@]2([H])C[C@@]4(C)[C@@]3([H])CC[C@]4(OC(C)=O)C(C)=O)=CC([C@H]5[C@@H]1C5)=O |
| InChIKey | UWFYSQMTEOIJJG-FDTZYFLXSA-N |
| InChI | InChI=1S/C24H29ClO4/c1-12(26)24(29-13(2)27)8-6-16-14-10-20(25)19-11-21(28)15-9-18(15)23(19,4)17(14)5-7-22(16,24)3/h10-11,14-18H,5-9H2,1-4H3/t14-,15+,16-,17-,18-,22-,23-,24-/m0/s1 |
| PubChem CID | 9880 |
| Target Point | Androgen Receptor |
| Passage | Endocrinology & Hormones |
| Background | Cyproterone Acetate is an androgen receptor antagonist. |
| Biological Activity | 是雄激素受体拮抗剂，IC50为7.1 nM，也是微弱的孕激素受体激动剂，具有微弱的孕激素和糖皮质激素活性。[1] |
| IC50 | Androgen Receptor: 7.1nM [1] |
| In Vitro | Cyproterone acetate具有显著的拮抗性能，也具有部分激活剂特性，在浓度相对较高时激活AR，EC50为4.0 μM。[1] 在10 nM 睾丸激素存在时，低浓度Cyproterone acetate抑制T-刺激的3XHRE-LUC转录，但是高浓度时刺激转录。[2] |
| In Vivo | Cyproterone acetate作用于生殖器官对重量有直接的负面影响，且显著降低精子数量和 Ca2+含量。 Cyproterone acetate处理的大鼠中，SOD和GST活性显著降低，NO显著提高，MDA含量反应睾丸的氧化状态。[3] |
| Animal Experiment | Rats were divided into 5 groups treated daily via an oral tube for two intervals 2 and 4 weeks，1st control，2nd E(Echinacea treated group in dose 63 mg kg(-1))，3rd CA(cyproterone acetate treated group in dose 25 mg kg(-1))，4th E+CA and 5th E as prophylactic one week before E+CA treatment with the same aforementioned E or CA doses. The body，testes，epididymis and vas deferens weights were recorded.[3] |
| Data Literature Source | [1] Sonneveld E，et al. Toxicol Sci. 2005，83(1)，136-148. [2] Attardi BJ，et al. Mol Cell Endocrinol. 2010，328(1-2)，16-21. [3] Arafa NM. Pak J Biol Sci. 2010，13(20)，966-976. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Cyproterone Acetate是雄激素受体拮抗剂。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Manual Download
