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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > AndrosteroneCAS：53-41-8
Molecular Formula：C19H30O2
Molecular Weight：290.44
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 53-41-8 |
| Name | Androsterone |
| Molecular Formula | C19H30O2 |
| Molecular Weight | 290.44 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-173-4 |
| MDL | MFCD01317504 |
| SMILES | C[C@]1([C@](CC2)([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC1)C2=O |
| InChIKey | QGXBDMJGAMFCBF-HLUDHZFRSA-N |
| InChI | InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18-,19-/m0/s1 |
| PubChem CID | 5879 |
| Target Point | Androgen Receptor;FXR |
| Passage | Endocrinology & Hormones;Metabolic Enzyme&Protease |
| Background | Androsterone is a metabolite of testosterone that activates the farnesoid X receptor (FXR). |
| Biological Activity | Androsterone 是睾酮的代谢产物，可以激活法尼醇 X 受体 (FXR)。[1-2] |
| In Vitro | 雄激素激活mFXR-LBD和hFXR-LBD，雄激素激活mFXR-LBD的能力强于hFXR-LBD。此外，用gal4-hFXR-LBD和SRC-1/VP16表达质粒进行的共转染研究表明，雄激素增强了SRC-1与hFXR-LBD的相互作用。包括H294S，S332V，R351H和Y361F在内的几种氨基酸变化显著降低了雄激素的活化[1]。雄激素(5α，3α-A)(10至100μM)也在体外切片模型中以浓度依赖性方式抑制癫痫样放电[2]。 |
| In Vivo | 雄激素治疗导致小异二聚体伴侣(SHP)的显著诱导，表明雄激素可能激活内源性FXR [1]。腹腔注射雄甾酮(5α，3α-A)以剂量依赖的方式保护小鼠免受以下模型中的癫痫发作(ED50，剂量以mg/kg保护50％的动物)：6 Hz电刺激(29.1)，戊四唑(43.5)，毛果芸香碱(105)，4-AP(215)和最大电休克(224)[2]。 |
| Cell Experiment | 使用AML-12细胞并在补充有10％胎牛血清，1％胰岛素转铁蛋白 - 硒混合物，40ng/mL地塞米松，100U/mL青霉素的DMEM/Ham's F12培养基的1：1混合物中培养，并且100μg/ mL链霉素。对于基因调控研究，将AML-12细胞以每孔4×10 5个细胞接种在生长培养基中的六孔板中。第二天，向培养基中加入包括雄甾酮或二甲基亚砜(DMSO)载体的处理。在添加处理后的不同时间，制备总RNA。单个基因的mRNA水平通过实时PCR确定[1]。 |
| Animal Experiment | 在研究开始前2周，将8至10周龄的阉割雄性小鼠喂食酪蛋白饮食2周。小鼠每天皮下注射0.1mL 90％玉米油/ 10％乙醇载体或10mg/mL雄甾酮。在第五次每日治疗后2小时，在光周期开始后约4小时，杀死动物。制备总RNA，并通过实时PCR确定特定基因的mRNA水平[1]。 |
| Data Literature Source | [1]. Wang S，et al. The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone. Endocrinology. 2006 Sep;147(9):4025-33. [2]. Kaminski RM，et al. Anticonvulsant activity of androsterone and etiocholanolone. Epilepsia. 2005 Jun;46(6):819-27. |
| Unit | Bottle |
| Specification | 100mg 10mM*1mL in DMSO 250mg |
Androsterone 是睾酮的代谢产物，可以激活法尼醇 X 受体 (FXR)。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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A mesoporous graphene @ zirconium-based metal–organic frameworks as a matrix and an adsorbent for steroid detection using surface-assisted laser desorption/ionization time-of-flight mass spectrometry
Click to check >>Author：Linyi Lu, Xin Qian, Fang Li, ShiJiang Qin, Yao Luo, Jinjing Tang, Kai Zhou, Guocan Zheng
IF：4.6010
Publish_to：JOURNAL OF CHROMATOGRAPHY A
PMID：37054637
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