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Application： ELISA
Reactivity：Mouse
Sensitivity：21.875pg/mL
Storage：2-8℃，6 months
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| Name | Mouse BMP7 ELISA Kit |
| Storage | 2-8℃，6 months |
| Detection Target | BMP7 |
| Sample Type | Serum，Plasma，Cell Culture Supernatant |
| Reactivity | Mouse |
| Application | ELISA |
| Quantitative/Qualitative | Quantitative |
| Detection Range | 43.75-2800pg/mL |
| Sensitivity | 21.875pg/mL |
| Precision | Both intra-plate and inter-plate variation coefficients were less than 10% |
| Recovery | 80%-120% |
| Assay Time | 3h15min |
| Swiss Prot | P23359 |
| Gene ID | 12162 |
| Background | Bone morphogenetic protein 7 (BMP7，also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene[1] and belong to BMP family and the TGF-β superfamily. Like other members of the BMP family of proteins，it plays a key role in the transformation of mesenchymal cells into bone and cartilage. It is inhibited by noggin and a similar protein，chordin，which are expressed in the Spemann-Mangold Organizer. BMP7 may be involved in bone homeostasis. It is expressed in the brain，kidneys and bladder. [2] BMP7 induces the phosphorylation of SMAD1 and SMAD5，which in turn induce transcription of numerous osteogenic genes.[3] It has been demonstrated that BMP7 treatment is sufficient to induce all of the genetic markers of osteoblast differentiation in many cell types.[2] Human recombinant BMP7 has surgical uses and is marketed under the brand name OP1. It can be used to aid in the fusion of vertebral bodies to prevent neurologic trauma.[4] Also in the treatment of tibial non-union，frequently in cases where a bone graft has failed.[5] BMP7 also has the potential for treatment of chronic kidney disease.[6][7] BMP7 administration has been proposed as a possible treatment for human infertility.[8] It was discovered that mice injected with BMP7 increased their production of good brown fat cells. [9] |
| Unit | Kit |
| Specification | 48T 96T |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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