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My CartCAS：105956-97-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to brown Solid
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| CAS | 105956-97-6 |
| Name | Clinafloxacin |
| Molecular Formula | C17H17ClFN3O3 |
| Molecular Weight | 365.79 |
| Solubility | Soluble in DMSO≥0.2mg/mL |
| Purity | ≥98% |
| Appearance | Off-white to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00865120 |
| SMILES | O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CC(N)CC4)=C3Cl)C1=O)O |
| InChIKey | QGPKADBNRMWEQR-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H17ClFN3O3/c18-13-14-10(5-12(19)15(13)21-4-3-8(20)6-21)16(23)11(17(24)25)7-22(14)9-1-2-9/h5,7-9H,1-4,6,20H2,(H,24,25) |
| PubChem CID | 60063 |
| Target Point | Antibiotic |
| Passage | Anti-infection |
| Background | Clinafloxacin is a potent broad-spectrum fluoroquinolone antibiotic that inhibits gram-positive， gram-negative， and anaerobic pathogens. |
| Biological Activity | 是一个喹诺酮羧酸类的广谱抗生素，可以抑制肺炎双球菌中 DNA旋转酶和拓扑异构酶IV。[1-3] |
| In Vitro | Clinafloxacin是一个新型的氟喹诺酮。在体外具有抗革兰氏阳性，革兰氏阴性，和厌氧病原体的广谱活性。Clinafloxacin对肺炎链球菌7785(MIC，0.125 微克/毫升)具有较高活性，并且非gyrA 或parC喹诺酮耐药突变单独对该活性具有更好的作用。[2]与ofloxacin，levofloxacin，sparfloxacin，grepafloxacin，以及trovafloxacin相比，Clinafloxacin被认为是最有效的抗S. pneumoniae氟喹诺酮，目前被认为是一个抗肺炎链球菌药。[3] |
| Data Literature Source | [1] Humphrey GH，et al. J Clin Pharmacol，1999，39(11)，1143-1150. [2] Pan XS，et al. Antimicrob Agents Chemother，1998，42(11)，2810-2816. [3] Jorgensen JH，et al. Antimicrob Agents Chemother，2000，44(1 |
| Unit | Bottle |
| Specification | 25mg 50mg |
是氟喹诺酮抗生素。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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