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My CartCAS：163252-36-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 163252-36-6 |
| Name | Clevudine |
| Molecular Formula | C10H13FN2O5 |
| Molecular Weight | 260.22 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-001-2 |
| MDL | MFCD00935785 |
| SMILES | O=C(C(C)=CN1[C@H]2O[C@@H](CO)[C@H](O)[C@H]2F)NC1=O |
| Target Point | HBV |
| Passage | Anti-infection |
| Background | Clevudine is a potent antiviral compound that can be used in anti-HBV related research. |
| Biological Activity | Clevudine是一种有效的抗HBV剂（在HepG22.2.15细胞中EC 50为0.1 μM）以及抗EB病毒剂，在多种细胞系，包括MT2，CEM，H1和HepG22.2.15和骨髓祖细胞具有低的细胞毒性。[1] |
| In Vitro | Clevudine被细胞由细胞中的胸苷激酶以及脱氧胞苷激酶代谢为磷酸形式，及随后的二磷酸和三磷酸。Clevudine是已知特异性作用于病毒DNA合成的，其三磷酸以剂量依赖的方式抑制HBV DNA的合成而不被掺入到DNA或链终止。[1] Clevudine导致在这些类似物的二磷酸和三磷酸代谢物的增加。Clevudine单磷酸(L-FMAUMP)是D-异构体的较弱的配体。[2] 在细胞培养中Clevudine很容易被磷酸化为5'-三磷酸形式化合物，这涉及Clevudine的作用机制。[3] |
| In Vivo | Clevudine以剂量依赖方式导致病毒复发的延迟中，在土拨鼠模型中减少了共价闭合环状DNA的损失。[3] Clevudine(10毫克/千克，IP)与 Emtricitabine(30毫克/千克，IP)联用导致土拨鼠中病毒复制的快速显著的抑制作用，血清WHV DNA下降10的4次方。在WHV感染的土拨鼠中，Clevudine(10毫克/公斤，腹腔注射)与 Emtricitabine(30毫克/千克，IP)联用导致肝脏和血液中有效且持久的抗嗜肝病毒作用。[4] |
| Animal Experiment | Six woodchuck hepatitis virus(WHV)-infected woodchucks received L-FMAU(10 mg/kg)plus FTC(30 mg/kg)intraperitoneally for 8 weeks. [4] |
| Data Literature Source | [1] Chong Y，et al. Bioorg Med Chem Lett，2002，12(23)，3459-3462. [2] Hu R，et al. Antimicrob Agents Chemother，2005，49(5)，2044-2049. [3] Korba BE，et al. Expert Rev Anti Infect Ther，2006，4(4)，549-561. [4] Jacquard AC，et al. Antimicrob Agents Chemother，2004，48(7 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Clevudine是一种有效的抗病毒化合物，可用于抗乙肝病毒的相关研究。
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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